| Literature DB >> 29092931 |
Shenglin Mei1,2, Clifford A Meyer3,4, Rongbin Zheng1,2, Qian Qin1,2, Qiu Wu1,2, Peng Jiang3,4, Bo Li3,4, Xiaohui Shi1,2, Binbin Wang1,2, Jingyu Fan1,2, Celina Shih5,6, Myles Brown4,7, Chongzhi Zang8,4,5,9, X Shirley Liu10,2,3,4.
Abstract
Cancer results from a breakdown of normal gene expression control, so the study of gene regulation is critical to cancer research. To gain insight into the transcriptional and epigenetic factors regulating abnormal gene expression patterns in cancers, we developed the Cistrome Cancer web resource (http://cistrome.org/CistromeCancer/). We conducted the systematic integration and modeling of over 10,000 tumor molecular profiles from The Cancer Genome Atlas (TCGA) with over 23,000 ChIP-seq and chromatin accessibility profiles from our Cistrome collection. The results include reconstruction of functional enhancer profiles, "super-enhancer" target genes, as well as predictions of active transcription factors and their target genes for each TCGA cancer type. Cistrome Cancer reveals novel insights from integrative analyses combining chromatin profiles with tumor molecular profiles and will be a useful resource to the cancer gene regulation community. Cancer Res; 77(21); e19-22. ©2017 AACR. ©2017 American Association for Cancer Research.Entities:
Mesh：
Substances：
Year: 2017 PMID： 29092931 PMCID： PMC5826647 DOI： 10.1158/0008-5472.CAN-17-0327
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701