Literature DB >> 29066795

A new eremophilane sesquiterpene from the fungus Xylaria sp. V-27 and inhibition activity against degranulation in RBL-2H3 cells.

Abdou Tchoukoua1, Takuma Suzuki2, Nanang Rudianto Ariefta2,3, Takuya Koseki2, Yusuke Okawa4, Ken-Ichi Kimura4, Yoshihito Shiono2,3.   

Abstract

A new eremophilane sesquiterpene, 13,13-dimethoxyintegric acid (1), together with known compound integric acid (2) have been isolated from a fungus, Xylaria sp. V-27, obtained from a dead branch. The structure of 1 was established by means of spectroscopic analyses. 1 and 2 promoted growth restoring activity against the mutant yeast strain (Saccharomyces cerevisiae (zds1Δ erg3Δ pdr1Δ pdr3Δ)) and inhibited degranulation of rat basophilic leukemia RBL-2H3 cells stimulated by immnunoglobulin G + 2,4-dinitrophenylated-bovine serum albumin (IgE+DNP-BSA), thapsigargin and A23187.

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Year:  2017        PMID： 29066795     DOI： 10.1038/ja.2017.120

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  Eremophilane-type sesquiterpenes from the fungus Xylaria sp. BCC 21097.

Authors:  Masahiko Isaka; Panida Chinthanom; Tanapong Boonruangprapa; Nattawut Rungjindamai; Umpava Pinruan
Journal:  J Nat Prod       Date:  2010-04-23       Impact factor: 4.050

2.  New eremophilane sesquiterpenoid compounds, eremoxylarins A and B directly inhibit calcineurin in a manner independent of immunophilin.

Authors:  Yukiko Ogasawara; Jun Yoshida; Yoshihito Shiono; Tokichi Miyakawa; Ken-ichi Kimura
Journal:  J Antibiot (Tokyo)       Date:  2008-08       Impact factor: 2.649

3.  07H239-A, a new cytotoxic eremophilane sesquiterpene from the marine-derived Xylariaceous fungus LL-07H239.

Authors:  Leonard A McDonald; Laurel R Barbieri; Valerie S Bernan; Jeffrey Janso; Peter Lassota; Guy T Carter
Journal:  J Nat Prod       Date:  2004-09       Impact factor: 4.050

4.  Yeast Ca(2+)-signal transduction inhibitors isolated from Dominican amber prevent the degranulation of RBL-2H3 cells through the inhibition of Ca(2+)-influx.

Authors:  Tomomi Abe; Miki Kobayashi; Yusuke Okawa; Tomoki Inui; Jun Yoshida; Hironori Higashio; Hisao Shinden; Shota Uesugi; Hiroyuki Koshino; Ken-Ichi Kimura
Journal:  Fitoterapia       Date:  2016-08-02       Impact factor: 2.882

5.  Novel sesquiterpenoids from the fermentation of Xylaria persicaria are selective ligands for the NPY Y5 receptor.

Authors:  Cameron J Smith; Nancy R Morin; Gerald F Bills; Anne W Dombrowski; Gino M Salituro; Scott K Smith; Annie Zhao; Douglas J MacNeil
Journal:  J Org Chem       Date:  2002-07-12       Impact factor: 4.354

6.  Four eremophilane sesquiterpenes from the mangrove endophytic fungus Xylaria sp. BL321.

Authors:  Yongxiang Song; Jiajian Wang; Hongbo Huang; Lin Ma; Jun Wang; Yucheng Gu; Lan Liu; Yongcheng Lin
Journal:  Mar Drugs       Date:  2012-02-06       Impact factor: 6.085
  6 in total

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