| Literature DB >> 20155932 |
Masahiko Isaka1, Panida Chinthanom, Tanapong Boonruangprapa, Nattawut Rungjindamai, Umpava Pinruan.
Abstract
Seven new eremophilane-type sesquiterpenoids (1-5, 7, and 8) and the known mairetolide F (6) were isolated from the endophytic Xylaria sp. BCC 21097. A new furofurandione (9) was also isolated from the fungal extract. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical reaction studies. Eremophilanolides possessing an alpha-methylene-gamma-lactone (1-3) exhibited moderate cytotoxic activities, while related analogues bearing an endo double bond (6 and 7) were inactive.Entities:
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Year: 2010 PMID: 20155932 DOI: 10.1021/np100030x
Source DB: PubMed Journal: J Nat Prod ISSN: 0163-3864 Impact factor: 4.050