Anna Rosenberg1, Tiia Ngandu2, Minna Rusanen3, Riitta Antikainen4, Lars Bäckman5, Satu Havulinna6, Tuomo Hänninen7, Tiina Laatikainen8, Jenni Lehtisalo9, Esko Levälahti10, Jaana Lindström10, Teemu Paajanen11, Markku Peltonen10, Hilkka Soininen12, Anna Stigsdotter-Neely13, Timo Strandberg14, Jaakko Tuomilehto15, Alina Solomon16, Miia Kivipelto17. 1. Institute of Clinical Medicine, Department of Neurology, University of Eastern Finland, Kuopio, Finland. Electronic address: anna.rosenberg@uef.fi. 2. Department of Public Health Solutions, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden. 3. Department of Public Health Solutions, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden; Department of Neurology, North Karelia Central Hospital, Joensuu, Finland. 4. Center for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland; Oulu City Hospital, Oulu, Finland. 5. Aging Research Center, Karolinska Institutet-Stockholm University, Stockholm, Sweden. 6. Aging, Disability and Functioning Unit, National Institute for Health and Welfare, Helsinki, Finland. 7. Department of Neurology, Kuopio University Hospital, Kuopio, Finland. 8. Department of Public Health Solutions, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Joint municipal authority for North Karelia Social and Health services, Joensuu, Finland. 9. Department of Public Health Solutions, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland. 10. Department of Public Health Solutions, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland. 11. Finnish Institute of Occupational Health, Helsinki, Finland. 12. Institute of Clinical Medicine, Department of Neurology, University of Eastern Finland, Kuopio, Finland; Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland. 13. Department of Psychology, Umeå University, Umeå, Sweden; Department of Social and Psychological Sciences, Karlstad University, Karlstad, Sweden. 14. Center for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland; University of Helsinki, Helsinki University Hospital, Helsinki, Finland. 15. Department of Public Health Solutions, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland; South Ostrobothnia Central Hospital, Seinäjoki, Finland. 16. Institute of Clinical Medicine, Department of Neurology, University of Eastern Finland, Kuopio, Finland; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden; Aging Research Center, Karolinska Institutet-Stockholm University, Stockholm, Sweden. 17. Institute of Clinical Medicine, Department of Neurology, University of Eastern Finland, Kuopio, Finland; Department of Public Health Solutions, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden; Aging Research Center, Karolinska Institutet-Stockholm University, Stockholm, Sweden; Stockholms Sjukhem, Research & Development Unit, Stockholm, Sweden.
Abstract
INTRODUCTION: The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition. METHODS: The FINGER recruited 1260 people from the general Finnish population (60-77 years, at risk for dementia). Participants were randomized 1:1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants' characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses. RESULTS:Sociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini-Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction > .05). CONCLUSIONS: The FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia.
RCT Entities:
INTRODUCTION: The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition. METHODS: The FINGER recruited 1260 people from the general Finnish population (60-77 years, at risk for dementia). Participants were randomized 1:1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants' characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses. RESULTS: Sociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini-Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction > .05). CONCLUSIONS: The FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia.
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