Shannon Halloway1, Michael E Schoeny2, Lisa L Barnes3, Zoe Arvanitakis4, Susan J Pressler5, Lynne T Braun6, Annabelle Santos Volgman7, Charlene Gamboa8, JoEllen Wilbur9. 1. Rush University, College of Nursing, 600 S. Paulina, Suite 1080, Chicago, IL 60612, USA. Electronic address: Shannon_Halloway@rush.edu. 2. Rush University, College of Nursing, 600 S. Paulina, Suite 1080, Chicago, IL 60612, USA. Electronic address: Michael_Schoeny@rush.edu. 3. Rush Alzheimer's Disease Center, 1750 W. Harrison, Chicago, IL 60612, USA. Electronic address: Lisa_L_Barnes@rush.edu. 4. Rush Alzheimer's Disease Center, 1750 W. Harrison, Chicago, IL 60612, USA; Rush Medical College, 600 S. Paulina Street, Suite 524, Chicago, IL 60612, USA. Electronic address: Zoe_Arvanitakis@rush.edu. 5. Indiana University, School of Nursing, 600 Barnhill Drive, Indianapolis, IN 46202, USA. Electronic address: sjpress@iu.edu. 6. Rush University, College of Nursing, 600 S. Paulina, Suite 1080, Chicago, IL 60612, USA. Electronic address: Lynne_T_Braun@rush.edu. 7. Rush Medical College, 600 S. Paulina Street, Suite 524, Chicago, IL 60612, USA. Electronic address: Annabelle_Volgman@rush.edu. 8. Rush University, College of Nursing, 600 S. Paulina, Suite 1080, Chicago, IL 60612, USA. Electronic address: Charlene_Gamboa@rush.edu. 9. Rush University, College of Nursing, 600 S. Paulina, Suite 1080, Chicago, IL 60612, USA. Electronic address: JoEllen_Wilbur@rush.edu.
Abstract
INTRODUCTION: Cognitive impairment (CI) and cardiovascular disease (CVD) disproportionately affect women compared to men, and CVD increases risk of CI. Physical activity and cognitive training can improve cognition in older adults and may have additive or synergistic effects. However, no combined intervention has targeted women with CVD or utilized a sustainable lifestyle approach. The purpose of the trial is to evaluate efficacy of MindMoves, a 24-week multimodal physical activity and cognitive training intervention, on cognition and serum biomarkers in older women with CVD. Three serum biomarkers (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor [VEGF], and insulin-like growth factor 1 [IGF-1]) were selected as a priori hypothesized indicators of the effects of physical activity and/or cognitive training on cognition. METHODS: The study design is a randomized controlled trial with a 2 × 2 factorial design, to determine independent and combined efficacies of Mind (tablet-based cognitive training) and Move (lifestyle physical activity with goal-setting and group meetings) on change in cognition (primary outcome) and serum biomarkers (secondary outcomes). We will recruit 254 women aged ≥65 years with CVD and without CI from cardiology clinics. Women will be randomized to one of four conditions: (1) Mind, (2) Move, (3) MindMoves, or (4) usual care. Data will be obtained from participants at baseline, 24, 48, and 72 weeks. DISCUSSION: This study will test efficacy of a lifestyle-focused intervention to prevent or delay cognitive impairment in older women with CVD and may identify relevant serum biomarkers that could be used as early indicators of intervention response.
INTRODUCTION: Cognitive impairment (CI) and cardiovascular disease (CVD) disproportionately affect women compared to men, and CVD increases risk of CI. Physical activity and cognitive training can improve cognition in older adults and may have additive or synergistic effects. However, no combined intervention has targeted women with CVD or utilized a sustainable lifestyle approach. The purpose of the trial is to evaluate efficacy of MindMoves, a 24-week multimodal physical activity and cognitive training intervention, on cognition and serum biomarkers in older women with CVD. Three serum biomarkers (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor [VEGF], and insulin-like growth factor 1 [IGF-1]) were selected as a priori hypothesized indicators of the effects of physical activity and/or cognitive training on cognition. METHODS: The study design is a randomized controlled trial with a 2 × 2 factorial design, to determine independent and combined efficacies of Mind (tablet-based cognitive training) and Move (lifestyle physical activity with goal-setting and group meetings) on change in cognition (primary outcome) and serum biomarkers (secondary outcomes). We will recruit 254 women aged ≥65 years with CVD and without CI from cardiology clinics. Women will be randomized to one of four conditions: (1) Mind, (2) Move, (3) MindMoves, or (4) usual care. Data will be obtained from participants at baseline, 24, 48, and 72 weeks. DISCUSSION: This study will test efficacy of a lifestyle-focused intervention to prevent or delay cognitive impairment in older women with CVD and may identify relevant serum biomarkers that could be used as early indicators of intervention response.
Authors: R S Wilson; D A Bennett; J L Bienias; N T Aggarwal; C F Mendes De Leon; M C Morris; J A Schneider; D A Evans Journal: Neurology Date: 2002-12-24 Impact factor: 9.910
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Authors: Joellen Wilbur; Susan W Buchholz; Diana M Ingram; Lynne T Braun; Tricia J Johnson; Louis Fogg; Arlene M Miller; Annabelle S Volgman; Judith McDevitt Journal: Res Nurs Health Date: 2013-06-14 Impact factor: 2.228