Fouad H Ebrahim1, Antonio C O Ruellas2, Beatriz Paniagua3, Erika Benavides1, Karl Jepsen4, Larry Wolford5, Joao Roberto Goncalves6, Lucia H S Cevidanes1. 1. School of Dentistry, University of Michigan, Ann Arbor, MI, USA. 2. School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Department of Pediatric Dentistry and Orthodontics, Visiting Post-doctoral Scholar, School of Dentistry, University of Michigan, Ann Arbor, MI, USA. Electronic address: antonioruellas@yahoo.com.br. 3. University of North Carolina, Chapel Hill, NC, USA. 4. Biomedical Sciences Research Building, University of Michigan, Ann Arbor, MI, USA. 5. Baylor University Medical Center, Dallas, TX, USA. 6. Araraquara Dental School, Paulista State University, Araraquara, SP, Brazil.
Abstract
OBJECTIVE: The aim of this study was to validate the ability of cone beam computed tomography (CBCT) to measure condylar internal trabecular bone structure and bone texture parameters accurately. STUDY DESIGN: Sixteen resected condyles of individuals undergoing temporomandibular joint replacement were collected and used as samples. These condyles were then radiographically imaged by using clinically oriented dental CBCT and research oriented micro-computed tomography (micro-CT). The CBCT scans were then compared with the gold standard micro-CT scans in terms of 21 bone imaging parameters. Descriptive histologic investigation of the specimens was also performed. RESULTS: Significant correlations were found for several imaging parameters between the CBCT and micro-CT images, including trabecular thickness (r = 0.92), trabecular separation (r = 0.78), bone volume (r = 0.90), bone surface area (r = 0.79), and degree of anisotropy measurements (r = 0.77). CONCLUSIONS: Measurements of trabecular thickness, trabecular separation, bone volume, bone surface area, and degree of anisotropy obtained from high-resolution dental CBCT images may be suitable bone imaging biomarkers that can be utilized clinically and in future research.
OBJECTIVE: The aim of this study was to validate the ability of cone beam computed tomography (CBCT) to measure condylar internal trabecular bone structure and bone texture parameters accurately. STUDY DESIGN: Sixteen resected condyles of individuals undergoing temporomandibular joint replacement were collected and used as samples. These condyles were then radiographically imaged by using clinically oriented dental CBCT and research oriented micro-computed tomography (micro-CT). The CBCT scans were then compared with the gold standard micro-CT scans in terms of 21 bone imaging parameters. Descriptive histologic investigation of the specimens was also performed. RESULTS: Significant correlations were found for several imaging parameters between the CBCT and micro-CT images, including trabecular thickness (r = 0.92), trabecular separation (r = 0.78), bone volume (r = 0.90), bone surface area (r = 0.79), and degree of anisotropy measurements (r = 0.77). CONCLUSIONS: Measurements of trabecular thickness, trabecular separation, bone volume, bone surface area, and degree of anisotropy obtained from high-resolution dental CBCT images may be suitable bone imaging biomarkers that can be utilized clinically and in future research.
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