| Literature DB >> 29051379 |
Koji Atarashi1,2, Wataru Suda1,3,4, Chengwei Luo5,6, Takaaki Kawaguchi1,2, Iori Motoo2, Seiko Narushima2, Yuya Kiguchi3, Keiko Yasuma1, Eiichiro Watanabe2, Takeshi Tanoue1,2, Christoph A Thaiss7, Mayuko Sato8, Kiminori Toyooka8, Heba S Said4,9, Hirokazu Yamagami10, Scott A Rice11, Dirk Gevers5, Ryan C Johnson12, Julia A Segre12, Kong Chen13, Jay K Kolls13, Eran Elinav7, Hidetoshi Morita14, Ramnik J Xavier5,6, Masahira Hattori15,4, Kenya Honda16,2.
Abstract
Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (TH1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.Entities:
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Year: 2017 PMID： 29051379 PMCID： PMC5682622 DOI： 10.1126/science.aan4526
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728