| Literature DB >> 29021545 |
Jason Ziveri1,2, Fabiola Tros1,2, Ida Chiara Guerrera1,3, Cerina Chhuon1,3, Mathilde Audry1,2, Marion Dupuis1,2, Monique Barel1,2, Sarantis Korniotis1,4, Simon Fillatreau1,4, Lara Gales5, Edern Cahoreau5, Alain Charbit6,7.
Abstract
The enzyme fructose-bisphosphate aldolase occupies a central position in glycolysis and gluconeogenesis pathways. Beyond its housekeeping role in metabolism, fructose-bisphosphate aldolase has been involved in additional functions and is considered as a potential target for drug development against pathogenic bacteria. Here, we address the role of fructose-bisphosphate aldolase in the bacterial pathogen Francisella novicida. We demonstrate that fructose-bisphosphate aldolase is important for bacterial multiplication in macrophages in the presence of gluconeogenic substrates. In addition, we unravel a direct role of this metabolic enzyme in transcription regulation of genes katG and rpoA, encoding catalase and an RNA polymerase subunit, respectively. We propose a model in which fructose-bisphosphate aldolase participates in the control of host redox homeostasis and the inflammatory immune response.The enzyme fructose-bisphosphate aldolase (FBA) plays central roles in glycolysis and gluconeogenesis. Here, Ziveri et al. show that FBA of the pathogen Francisella novicida acts, in addition, as a transcriptional regulator and is important for bacterial multiplication in macrophages.Entities:
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Year: 2017 PMID： 29021545 PMCID： PMC5636795 DOI： 10.1038/s41467-017-00889-7
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919