Literature DB >> 29019068

Early epithelial complications of accelerated trans-epithelial corneal crosslinking in treatment of keratoconus: a case series.

Sharon S W Chow1, Tommy C Y Chan2, Ian Y H Wong3, Michelle C Y Fan1, Jimmy S M Lai3, Alex L K Ng4.   

Abstract

BACKGROUND: To report a case series of early postoperative complications following combined accelerated corneal crosslinking (CXL) and trans-epithelial technique in keratoconus. CASE PRESENTATIONS: Eleven eyes underwent accelerated trans-epithelial CXL (18 mW/cm2 for 5 min). Seven eyes (64%) developed complications in the first week postoperatively. Five eyes had large epithelial defects, and two eyes were complicated with diffuse punctate epithelial erosions. Early transient stromal haze was seen in eyes with epithelial complications. Anterior segment optical coherence tomography showed a faint demarcation line in six eyes (55%) with epithelial complications.
CONCLUSION: A significant number of eyes developed epithelial complications shortly after combined accelerated trans-epithelial CXL, which defeated the benefits of leaving the epithelium intact.

Entities:  

Keywords:  Accelerated crosslinking; Corneal collagen crosslinking; Keratoconus; Trans-epithelial crosslinking

Mesh:

Substances:

Year:  2017        PMID: 29019068     DOI: 10.1007/s10792-017-0734-9

Source DB:  PubMed          Journal:  Int Ophthalmol        ISSN: 0165-5701            Impact factor:   2.031


  18 in total

Review 1.  Interaction of ultraviolet light with the cornea: clinical implications for corneal crosslinking.

Authors:  Marco Lombardo; Giuseppe Pucci; Riccardo Barberi; Giuseppe Lombardo
Journal:  J Cataract Refract Surg       Date:  2014-12-23       Impact factor: 3.351

2.  Transepithelial corneal collagen crosslinking for keratoconus: qualitative investigation by in vivo HRT II confocal analysis.

Authors:  Aldo Caporossi; Cosimo Mazzotta; Stefano Baiocchi; Tomaso Caporossi; Anna Lucia Paradiso
Journal:  Eur J Ophthalmol       Date:  2012       Impact factor: 2.597

3.  Transepithelial corneal collagen crosslinking: bilateral study.

Authors:  Massimo Filippello; Edoardo Stagni; David O'Brart
Journal:  J Cataract Refract Surg       Date:  2011-11-21       Impact factor: 3.351

4.  Evaluation of corneal changes after conventional versus accelerated corneal cross-linking: a randomized controlled trial.

Authors:  Hesam Hashemian; Mahmoud Jabbarvand; Mehdi Khodaparast; Kambiz Ameli
Journal:  J Refract Surg       Date:  2014-12       Impact factor: 3.573

5.  Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus.

Authors:  Gregor Wollensak; Eberhard Spoerl; Theo Seiler
Journal:  Am J Ophthalmol       Date:  2003-05       Impact factor: 5.258

6.  Transepithelial corneal collagen cross-linking in keratoconus.

Authors:  Antonio Leccisotti; Tahmina Islam
Journal:  J Refract Surg       Date:  2010-02-15       Impact factor: 3.573

7.  A study comparing standard and transepithelial collagen cross-linking riboflavin solutions: epithelial findings and pain scores.

Authors:  Erdem Yuksel; Shahin Novruzlu; Mehmet C Ozmen; Kamil Bilgihan
Journal:  J Ocul Pharmacol Ther       Date:  2015-04-28       Impact factor: 2.671

8.  Corneal crosslinking: riboflavin concentration in corneal stroma exposed with and without epithelium.

Authors:  Stefano Baiocchi; Cosimo Mazzotta; Daniela Cerretani; Tomaso Caporossi; Aldo Caporossi
Journal:  J Cataract Refract Surg       Date:  2009-05       Impact factor: 3.351

9.  Complication and failure rates after corneal crosslinking.

Authors:  Tobias Koller; Michael Mrochen; Theo Seiler
Journal:  J Cataract Refract Surg       Date:  2009-08       Impact factor: 3.351

10.  The Biomechanical Effect of Corneal Collagen Cross-Linking (CXL) With Riboflavin and UV-A is Oxygen Dependent.

Authors:  Olivier Richoz; Arthur Hammer; David Tabibian; Zisis Gatzioufas; Farhad Hafezi
Journal:  Transl Vis Sci Technol       Date:  2013-12-11       Impact factor: 3.283

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  5 in total

1.  Prospective 2-year study of accelerated pulsed transepithelial corneal crosslinking outcomes for Keratoconus.

Authors:  Mohammed Ziaei; Hans Vellara; Akilesh Gokul; Dipika Patel; Charles N J McGhee
Journal:  Eye (Lond)       Date:  2019-07-04       Impact factor: 3.775

2.  Transepithelial Accelerated Corneal Collagen Cross-Linking: Two-Year Results.

Authors:  Ana Maria Cunha; Tiago Sardinha; Luís Torrão; Raúl Moreira; Fernando Falcão-Reis; João Pinheiro-Costa
Journal:  Clin Ophthalmol       Date:  2020-08-14

Review 3.  Nonlinear optical crosslinking (NLO CXL) for correcting refractive errors.

Authors:  Samantha Bradford; Eric Mikula; Tibor Juhasz; Donald J Brown; James V Jester
Journal:  Exp Eye Res       Date:  2020-08-23       Impact factor: 3.467

4.  Enhanced Transepithelial Riboflavin Delivery Using Femtosecond Laser-Machined Epithelial Microchannels.

Authors:  Samantha Bradford; Eric Mikula; Yilu Xie; Tibor Juhasz; Donald J Brown; James V Jester
Journal:  Transl Vis Sci Technol       Date:  2020-05-11       Impact factor: 3.283

Review 5.  Complications of corneal collagen cross-linking.

Authors:  Richa Agarwal; Parul Jain; Ritu Arora
Journal:  Indian J Ophthalmol       Date:  2022-05       Impact factor: 2.969

  5 in total

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