PURPOSE: To evaluate epithelial signs and pain after epithelial-on corneal collagen cross-linking (Epi-on CCL) with new transepithelial riboflavin formulation and epithelial-off corneal collagen cross-linking (Epi-off CCL) with standard riboflavin formulation and to compare pain and duration of epithelial healing between both techniques. METHODS: Thirty-nine eyes of 39 patients undergoing Epi-on CCL and 39 eyes of 39 patients undergoing Epi-off CCL were evaluated. Corneal epithelial signs and durations of corneal epithelial healing and subjective pain scores after the procedures were recorded and compared between 2 groups. RESULTS: Total epithelialization was observed after 2.7 ± 0.7 days in Epi-on CCL and 2.3 ± 0.4 days in Epi-off CCL (P = 0.006). The mean pain score on the first day was 3.1 ± 0.6 in Epi-on CCL and 2.3 ± 0.4 in Epi-off CCL with a significant difference (P = 0.0001). CONCLUSION: The epithelial damage was observed in both procedures; also, the epithelial healing time was longer in Epi-on CCL and it is of great importance that the patients should have therapeutic contact lenses until the epithelium heals in both procedures. The Epi-off CCL group had less pain scores than the Epi-on CCL group and more pain problems after Epi-on CCL still remains. The patient should be informed about pain, even if the Epi-on CCL procedure was performed.
PURPOSE: To evaluate epithelial signs and pain after epithelial-on corneal collagen cross-linking (Epi-on CCL) with new transepithelial riboflavin formulation and epithelial-off corneal collagen cross-linking (Epi-off CCL) with standard riboflavin formulation and to compare pain and duration of epithelial healing between both techniques. METHODS: Thirty-nine eyes of 39 patients undergoing Epi-on CCL and 39 eyes of 39 patients undergoing Epi-off CCL were evaluated. Corneal epithelial signs and durations of corneal epithelial healing and subjective pain scores after the procedures were recorded and compared between 2 groups. RESULTS: Total epithelialization was observed after 2.7 ± 0.7 days in Epi-on CCL and 2.3 ± 0.4 days in Epi-off CCL (P = 0.006). The mean pain score on the first day was 3.1 ± 0.6 in Epi-on CCL and 2.3 ± 0.4 in Epi-off CCL with a significant difference (P = 0.0001). CONCLUSION: The epithelial damage was observed in both procedures; also, the epithelial healing time was longer in Epi-on CCL and it is of great importance that the patients should have therapeutic contact lenses until the epithelium heals in both procedures. The Epi-off CCL group had less pain scores than the Epi-on CCL group and more pain problems after Epi-on CCL still remains. The patient should be informed about pain, even if the Epi-on CCL procedure was performed.
Authors: Sharon S W Chow; Tommy C Y Chan; Ian Y H Wong; Michelle C Y Fan; Jimmy S M Lai; Alex L K Ng Journal: Int Ophthalmol Date: 2017-10-10 Impact factor: 2.031
Authors: Ana Castro-Balado; Cristina Mondelo-García; Letricia Barbosa-Pereira; Iria Varela-Rey; Ignacio Novo-Veleiro; Néstor Vázquez-Agra; José Ramón Antúnez-López; Enrique José Bandín-Vilar; Raquel Sendón-García; Manuel Busto-Iglesias; Ana Rodríguez-Bernaldo de Quirós; Laura García-Quintanilla; Miguel González-Barcia; Irene Zarra-Ferro; Francisco J Otero-Espinar; David Rey-Bretal; José Ramón Lago-Quinteiro; Luis Valdés-Cuadrado; Carlos Rábade-Castedo; María Carmen Del Río-Garma; Carlos Crespo-Diz; Olga Delgado-Sánchez; Pablo Aguiar; Gema Barbeito-Castiñeiras; María Luisa Pérez Del Molino-Bernal; Rocío Trastoy-Pena; Rossana Passannante; Jordi Llop; Antonio Pose-Reino; Anxo Fernández-Ferreiro Journal: Pharmaceutics Date: 2021-03-05 Impact factor: 6.321