Natashia Swalve1, John R Smethells2, Rebecca Younk3, Jared Mitchell3, Ben Dougen3, Marilyn E Carroll4. 1. Department of Psychology, Alma College, Alma, MI, 48801, USA. 2. Department of Medicine, Minneapolis Medical Research Foundation, Minneapolis, MN, 55414, USA. 3. Department of Psychiatry, University of Minnesota, MMC 392 UMHC, Minneapolis, MN, 55455, USA. 4. Department of Psychiatry, University of Minnesota, MMC 392 UMHC, Minneapolis, MN, 55455, USA. mcarroll@umn.edu.
Abstract
RATIONALE: Previous work indicated that progesterone (PRO) reduced impulsive choice for cocaine in female but not male rats (Smethells et al. Psychopharmacology 233:2999-3008, 2016). Impulsive action, typically measured by responding for a reinforcer during a signaled period of nonavailability of natural reinforcers, predicts initiation and escalation of drug use in animals and humans. The present study examined impulsive action for cocaine using PRO in male and female rats trained on a go/no-go task. OBJECTIVE: Rats were trained on a go/no-go task to respond for cocaine infusions (0.4 mg/kg/inf). During the "go" component, responding was reinforced on a VI 30-s schedule, whereas during the "no-go" component, withholding a response was reinforced on a differential reinforcement of other behavior (DRO) 30-s schedule. A response during the no-go component resets the DRO timer and served as a measure of impulsive action. After baseline responding was established, rats were pretreated with vehicle (VEH) or PRO (0.5 mg/kg), and DRO resets and responding during the go component for cocaine were compared in males vs. females. RESULTS: DRO resets were significantly lower following PRO treatment compared to VEH in female, but not male, rats. Response rates and overall infusions during the go component were not significantly altered by PRO in either females or males. CONCLUSION: Treatment with PRO resulted in a sex-specific reduction in impulsive action for cocaine, while not affecting cocaine self-administration.
RATIONALE: Previous work indicated that progesterone (PRO) reduced impulsive choice for cocaine in female but not male rats (Smethells et al. Psychopharmacology 233:2999-3008, 2016). Impulsive action, typically measured by responding for a reinforcer during a signaled period of nonavailability of natural reinforcers, predicts initiation and escalation of drug use in animals and humans. The present study examined impulsive action for cocaine using PRO in male and female rats trained on a go/no-go task. OBJECTIVE:Rats were trained on a go/no-go task to respond for cocaine infusions (0.4 mg/kg/inf). During the "go" component, responding was reinforced on a VI 30-s schedule, whereas during the "no-go" component, withholding a response was reinforced on a differential reinforcement of other behavior (DRO) 30-s schedule. A response during the no-go component resets the DRO timer and served as a measure of impulsive action. After baseline responding was established, rats were pretreated with vehicle (VEH) or PRO (0.5 mg/kg), and DRO resets and responding during the go component for cocaine were compared in males vs. females. RESULTS: DRO resets were significantly lower following PRO treatment compared to VEH in female, but not male, rats. Response rates and overall infusions during the go component were not significantly altered by PRO in either females or males. CONCLUSION: Treatment with PRO resulted in a sex-specific reduction in impulsive action for cocaine, while not affecting cocaine self-administration.
Entities:
Keywords:
Drug addiction; Go/no-go; Impulsive action; Progesterone; Rats; Sex differences
Authors: Louis A Giordano; Warren K Bickel; George Loewenstein; Eric A Jacobs; Lisa Marsch; Gary J Badger Journal: Psychopharmacology (Berl) Date: 2002-07-13 Impact factor: 4.530
Authors: Jennifer L Perry; Erin B Larson; Jonathan P German; Gregory J Madden; Marilyn E Carroll Journal: Psychopharmacology (Berl) Date: 2004-08-27 Impact factor: 4.530
Authors: Nicole L Tosun; Sharon S Allen; Lynn E Eberly; Meng Yao; William W Stoops; Justin C Strickland; Katherine A Harrison; Mustafa al'Absi; Marilyn E Carroll Journal: Drug Alcohol Depend Date: 2018-09-01 Impact factor: 4.492
Authors: Jeffrey S Darling; Daniel W Bayless; Lauren R Dartez; Joshua J Taylor; Arjun Mehrotra; William L Smith; Jill M Daniel Journal: Behav Brain Res Date: 2020-08-02 Impact factor: 3.332
Authors: Caitlin A Orsini; Shelby L Blaes; Caesar M Hernandez; Sara M Betzhold; Hassan Perera; Alexa-Rae Wheeler; Tyler W Ten Eyck; Tyler S Garman; Jennifer L Bizon; Barry Setlow Journal: Neuropsychopharmacology Date: 2020-09-12 Impact factor: 7.853