Literature DB >> 29017051

Tumor Suppression by p53: Bring in the Hippo!

Yael Aylon1, Moshe Oren2.   

Abstract

In this issue of Cancer Cell, Mello et al. investigated how p53 suppresses pancreatic cancer and discovered a key role for the tyrosine phosphatase PTPN14, a p53 transcriptional target. PTPN14 restrains YAP, curbing its potential oncogenic effects. The p53-PTPN14-YAP axis highlights the importance of signaling pathway coordination in cancer prevention.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2017        PMID： 29017051     DOI： 10.1016/j.ccell.2017.09.010

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  4 in total

1.  Trp53 controls chondrogenesis and endochondral ossification by negative regulation of TAZ activity and stability via β-TrCP-mediated ubiquitination.

Authors:  Yang Li; Shu-Ting Yang; Shuying Yang
Journal:  Cell Death Discov       Date:  2022-07-12

2.  Cytotoxic effects of auraptene against a human malignant glioblastoma cell line.

Authors:  Amir R Afshari; Mostafa Karimi Roshan; Mohammad Soukhtanloo; Ahmad Ghorbani; Farzad Rahmani; Mohammad Jalili-Nik; Mohammad Mahdi Vahedi; Azar Hoseini; Hamid R Sadeghnia; Hamid Mollazadeh; Seyed Hadi Mousavi
Journal:  Avicenna J Phytomed       Date:  2019 Jul-Aug

3.  Cucurbitacin B Inhibits the Hippo-YAP Signaling Pathway and Exerts Anticancer Activity in Colorectal Cancer Cells.

Authors:  Yanting Chai; Ke Xiang; Yezi Wu; Te Zhang; Ying Liu; Xuewen Liu; Weiguo Zhen; Yuan Si
Journal:  Med Sci Monit       Date:  2018-12-19

4.  SEPT6_TRIM33 Gene Fusion and Mutated TP53 Pathway Associate With Unfavorable Prognosis in Patients With B-Cell Lymphomas.

Authors:  Haiying Fu; Huarong Zhou; Yanyan Qiu; Jianfei Wang; Zhiming Ma; Hongping Li; Feng Zhang; Chenxi Qiu; Jianzhen Shen; Tingbo Liu
Journal:  Front Oncol       Date:  2021-12-01       Impact factor: 6.244
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.