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Literature DB >> 29017047

Cell Biology: Capturing Formin's Mechano-Inhibition.

Abstract

Formins polymerize actin filaments for the cytokinetic contractile ring. Using in vitro reconstitution of fission yeast contractile ring precursor nodes containing formins and myosin, a new study shows that formin-mediated polymerization is strongly inhibited upon the capture and pulling of actin filaments by myosin, a result that has broad implications for cellular mechanosensing.

Entities: Chemical Disease Gene Species

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Year: 2017 PMID： 29017047 PMCID： PMC5661962 DOI： 10.1016/j.cub.2017.08.020

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

20 in total

1. Assembly mechanism of the contractile ring for cytokinesis by fission yeast.

Authors: Dimitrios Vavylonis; Jian-Qiu Wu; Steven Hao; Ben O'Shaughnessy; Thomas D Pollard
Journal: Science Date: 2007-12-13 Impact factor: 47.728

2. Tension modulates actin filament polymerization mediated by formin and profilin.

Authors: Naomi Courtemanche; Ja Yil Lee; Thomas D Pollard; Eric C Greene
Journal: Proc Natl Acad Sci U S A Date: 2013-05-28 Impact factor: 11.205

3. Formin mDia1 senses and generates mechanical forces on actin filaments.

Authors: Antoine Jégou; Marie-France Carlier; Guillaume Romet-Lemonne
Journal: Nat Commun Date: 2013 Impact factor: 14.919

Review 4. Unleashing formins to remodel the actin and microtubule cytoskeletons.

Authors: Melissa A Chesarone; Amy Grace DuPage; Bruce L Goode
Journal: Nat Rev Mol Cell Biol Date: 2009-12-09 Impact factor: 94.444

Review 5. Keeping the focus on biophysics and actin filaments in Nagoya: A report of the 2016 "now in actin" symposium.

Authors: Ikuko Fujiwara; Akihiro Narita
Journal: Cytoskeleton (Hoboken) Date: 2017-07-21

6. Computational simulation of formin-mediated actin polymerization predicts homologue-dependent mechanosensitivity.

Authors: Derek Bryant; Lara Clemens; Jun Allard
Journal: Cytoskeleton (Hoboken) Date: 2016-11-11

7. Phylogenetic analysis of the formin homology 2 domain.

Authors: Henry N Higgs; Kevin J Peterson
Journal: Mol Biol Cell Date: 2004-10-27 Impact factor: 4.138

8. ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.

Authors: David B Heisler; Elena Kudryashova; Dmitry O Grinevich; Cristian Suarez; Jonathan D Winkelman; Konstantin G Birukov; Sainath R Kotha; Narasimham L Parinandi; Dimitrios Vavylonis; David R Kovar; Dmitri S Kudryashov
Journal: Science Date: 2015-07-31 Impact factor: 47.728

Cell Biology: Capturing Formin's Mechano-Inhibition.

1. Assembly mechanism of the contractile ring for cytokinesis by fission yeast.

2. Tension modulates actin filament polymerization mediated by formin and profilin.

3. Formin mDia1 senses and generates mechanical forces on actin filaments.

Review 4. Unleashing formins to remodel the actin and microtubule cytoskeletons.

Review 5. Keeping the focus on biophysics and actin filaments in Nagoya: A report of the 2016 "now in actin" symposium.

6. Computational simulation of formin-mediated actin polymerization predicts homologue-dependent mechanosensitivity.

7. Phylogenetic analysis of the formin homology 2 domain.

8. ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.

Review 9. Understanding cytokinesis: lessons from fission yeast.

10. The functionally distinct fission yeast formins have specific actin-assembly properties.

Review 1. Molecular form and function of the cytokinetic ring.

2. Computational modeling highlights the role of the disordered Formin Homology 1 domain in profilin-actin transfer.