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Literature DB >> 19997130

Unleashing formins to remodel the actin and microtubule cytoskeletons.

Melissa A Chesarone¹, Amy Grace DuPage, Bruce L Goode.

Abstract

Formins are highly conserved proteins that have essential roles in remodelling the actin and microtubule cytoskeletons to influence eukaryotic cell shape and behaviour. Recent work has identified numerous cellular factors that locally recruit, activate or inactivate formins to bridle and unleash their potent effects on actin nucleation and elongation. The effects of formins on microtubules have also begun to be described, which places formins in a prime position to coordinate actin and microtubule dynamics. The emerging complexity in the mechanisms governing formins mirrors the wide range of essential functions that they perform in cell motility, cell division and cell and tissue morphogenesis.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19997130 DOI： 10.1038/nrm2816

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

167 in total

1. An FH domain-containing Bnr1p is a multifunctional protein interacting with a variety of cytoskeletal proteins in Saccharomyces cerevisiae.

Authors: M Kikyo; K Tanaka; T Kamei; K Ozaki; T Fujiwara; E Inoue; Y Takita; Y Ohya; Y Takai
Journal: Oncogene Date: 1999-11-25 Impact factor: 9.867

Review 2. [Structure and function of Formin homology 2 domain].

Authors: Takanori Otomo; Michael K Rosen
Journal: Tanpakushitsu Kakusan Koso Date: 2005-08

3. The Drosophila formin DAAM regulates the tracheal cuticle pattern through organizing the actin cytoskeleton.

Authors: Tamás Matusek; Alexandre Djiane; Ferenc Jankovics; Damian Brunner; Marek Mlodzik; József Mihály
Journal: Development Date: 2006-03 Impact factor: 6.868

4. Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells.

Authors: Floria Lizárraga; Renaud Poincloux; Maryse Romao; Guillaume Montagnac; Gaëlle Le Dez; Isabelle Bonne; Guillem Rigaill; Graça Raposo; Philippe Chavrier
Journal: Cancer Res Date: 2009-03-10 Impact factor: 12.701

5. FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages.

Authors: S Yayoshi-Yamamoto; I Taniuchi; T Watanabe
Journal: Mol Cell Biol Date: 2000-09 Impact factor: 4.272

6. Mitf regulation of Dia1 controls melanoma proliferation and invasiveness.

Authors: Suzanne Carreira; Jane Goodall; Laurence Denat; Mercedes Rodriguez; Paolo Nuciforo; Keith S Hoek; Alessandro Testori; Lionel Larue; Colin R Goding
Journal: Genes Dev Date: 2006-12-15 Impact factor: 11.361

7. Formin1 disruption confers oligodactylism and alters Bmp signaling.

Authors: Fen Zhou; Philip Leder; Aimée Zuniga; Markus Dettenhofer
Journal: Hum Mol Genet Date: 2009-04-20 Impact factor: 6.150

8. Formin-dependent synaptic growth: evidence that Dlar signals via Diaphanous to modulate synaptic actin and dynamic pioneer microtubules.

Authors: Catherine Pawson; Benjamin A Eaton; Graeme W Davis
Journal: J Neurosci Date: 2008-10-29 Impact factor: 6.167

9. A new model for asymmetric spindle positioning in mouse oocytes.

Authors: Melina Schuh; Jan Ellenberg
Journal: Curr Biol Date: 2008-12-08 Impact factor: 10.834

10. The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition.

Authors: Fang Li; Henry N Higgs
Journal: Curr Biol Date: 2003-08-05 Impact factor: 10.834

240 in total

1. Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility.

Authors: Cat M Haglund; Julie E Choe; Colleen T Skau; David R Kovar; Matthew D Welch
Journal: Nat Cell Biol Date: 2010-10-24 Impact factor: 28.824

2. mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation.

Authors: Wah Ing Goh; Kim Buay Lim; Thankiah Sudhaharan; Kai Ping Sem; Wenyu Bu; Ai Mei Chou; Sohail Ahmed
Journal: J Biol Chem Date: 2011-12-17 Impact factor: 5.157

Review 3. New insights into the role of plant formins: regulating the organization of the actin and microtubule cytoskeleton.

Authors: Jiaojiao Wang; Xiuhua Xue; Haiyun Ren
Journal: Protoplasma Date: 2012-01-04 Impact factor: 3.356

Unleashing formins to remodel the actin and microtubule cytoskeletons.

1. An FH domain-containing Bnr1p is a multifunctional protein interacting with a variety of cytoskeletal proteins in Saccharomyces cerevisiae.

Review 2. [Structure and function of Formin homology 2 domain].

3. The Drosophila formin DAAM regulates the tracheal cuticle pattern through organizing the actin cytoskeleton.

4. Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells.

5. FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages.

6. Mitf regulation of Dia1 controls melanoma proliferation and invasiveness.

7. Formin1 disruption confers oligodactylism and alters Bmp signaling.

8. Formin-dependent synaptic growth: evidence that Dlar signals via Diaphanous to modulate synaptic actin and dynamic pioneer microtubules.

9. A new model for asymmetric spindle positioning in mouse oocytes.

10. The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition.

1. Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility.

2. mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation.

Review 3. New insights into the role of plant formins: regulating the organization of the actin and microtubule cytoskeleton.

4. Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation.

Review 5. Actin organization and dynamics in filamentous fungi.

Review 6. The podocyte cytoskeleton--key to a functioning glomerulus in health and disease.

7. Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein.

8. Nucleation geometry governs ordered actin networks structures.

Review 9. Cell adhesion: integrating cytoskeletal dynamics and cellular tension.

Review 10. Bacterial nucleators: actin' on actin.