Paula Trujillo1,2, Paul E Summers3, Alex K Smith4, Seth A Smith5,6, Luca T Mainardi7, Sergio Cerutti7, Daniel O Claassen2, Antonella Costa1. 1. Department of Neuroradiology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, MI, Italy. 2. Department of Neurology, Vanderbilt University Medical Center, 1500 21st Avenue South, Suite 3000, Nashville, TN, 37232, USA. 3. Department of Neuroradiology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, MI, Italy. paul.summers@ieo.it. 4. Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, OX3 9DU, UK. 5. Vanderbilt University Institute of Imaging Science, Vanderbilt University, 1161 21st Avenue South, Medical Center North, AA-1105, Nashville, TN, 37232, USA. 6. Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37232, USA. 7. Department of Electronics, Information and Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, MI, Italy.
Abstract
PURPOSE: We sought to measure quantitative magnetization transfer (qMT) properties of the substantia nigra pars compacta (SNc) in patients with Parkinson's disease (PD) and healthy controls (HCs) using a full qMT analysis and determine whether a rapid single-point measurement yields equivalent results for pool size ratio (PSR). METHODS: Sixteen different MT-prepared MRI scans were obtained at 3 T from 16 PD patients and eight HCs, along with B1, B0, and relaxation time maps. Maps of PSR, free and macromolecular pool transverse relaxation times ([Formula: see text], [Formula: see text]) and rate of MT exchange between pools (k mf ) were generated using a full qMT model. PSR maps were also generated using a single-point qMT model requiring just two MT-prepared images. qMT parameter values of the SNc, red nucleus, cerebral crus, and gray matter were compared between groups and methods. RESULTS: PSR of the SNc was the only qMT parameter to differ significantly between groups (p < 0.05). PSR measured via single-point analysis was less variable than with the full MT model, provided slightly better differentiation of PD patients from HCs (area under curve 0.77 vs. 0.75) with sensitivity of 0.75 and specificity of 0.87, and was better than transverse relaxation time in distinguishing PD patients from HCs (area under curve 0.71, sensitivity 0.87, and specificity 0.50). CONCLUSION: The increased PSR observed in the SNc of PD patients may provide a novel biomarker of PD, possibly associated with an increased macromolecular content. Single-point PSR mapping with reduced variability and shorter scan times relative to the full qMT model appears clinically feasible.
PURPOSE: We sought to measure quantitative magnetization transfer (qMT) properties of the substantia nigra pars compacta (SNc) in patients with Parkinson's disease (PD) and healthy controls (HCs) using a full qMT analysis and determine whether a rapid single-point measurement yields equivalent results for pool size ratio (PSR). METHODS: Sixteen different MT-prepared MRI scans were obtained at 3 T from 16 PDpatients and eight HCs, along with B1, B0, and relaxation time maps. Maps of PSR, free and macromolecular pool transverse relaxation times ([Formula: see text], [Formula: see text]) and rate of MT exchange between pools (k mf ) were generated using a full qMT model. PSR maps were also generated using a single-point qMT model requiring just two MT-prepared images. qMT parameter values of the SNc, red nucleus, cerebral crus, and gray matter were compared between groups and methods. RESULTS:PSR of the SNc was the only qMT parameter to differ significantly between groups (p < 0.05). PSR measured via single-point analysis was less variable than with the full MT model, provided slightly better differentiation of PDpatients from HCs (area under curve 0.77 vs. 0.75) with sensitivity of 0.75 and specificity of 0.87, and was better than transverse relaxation time in distinguishing PDpatients from HCs (area under curve 0.71, sensitivity 0.87, and specificity 0.50). CONCLUSION: The increased PSR observed in the SNc of PDpatients may provide a novel biomarker of PD, possibly associated with an increased macromolecular content. Single-point PSR mapping with reduced variability and shorter scan times relative to the full qMT model appears clinically feasible.
Entities:
Keywords:
Magnetization transfer; Neuromelanin; Parkinson’s disease; Substantia nigra
Authors: Richard D Dortch; Ke Li; Daniel F Gochberg; E Brian Welch; Adrienne N Dula; Ashish A Tamhane; John C Gore; Seth A Smith Journal: Magn Reson Med Date: 2011-05-23 Impact factor: 4.668
Authors: Paula Trujillo; Paul E Summers; Emanuele Ferrari; Fabio A Zucca; Michela Sturini; Luca T Mainardi; Sergio Cerutti; Alex K Smith; Seth A Smith; Luigi Zecca; Antonella Costa Journal: Magn Reson Med Date: 2016-12-26 Impact factor: 4.668
Authors: Paula Trujillo; Alex K Smith; Paul E Summers; Luca M Mainardi; Sergio Cerutti; Seth A Smith; Antonella Costa Journal: Conf Proc IEEE Eng Med Biol Soc Date: 2015
Authors: Xiangchuan Chen; Daniel E Huddleston; Jason Langley; Sinyeob Ahn; Christopher J Barnum; Stewart A Factor; Allan I Levey; Xiaoping Hu Journal: Magn Reson Imaging Date: 2014-07-31 Impact factor: 2.546
Authors: Hunter R Underhill; Robert C Rostomily; Andrei M Mikheev; Chun Yuan; Vasily L Yarnykh Journal: Neuroimage Date: 2010-10-26 Impact factor: 6.556
Authors: Ioannis U Isaias; Paula Trujillo; Paul Summers; Giorgio Marotta; Luca Mainardi; Gianni Pezzoli; Luigi Zecca; Antonella Costa Journal: Front Aging Neurosci Date: 2016-08-22 Impact factor: 5.750
Authors: Alex K Smith; Kevin J Ray; James R Larkin; Martin Craig; Seth A Smith; Michael A Chappell Journal: Magn Reson Med Date: 2020-02-18 Impact factor: 4.668
Authors: Nikos Priovoulos; Stan C J van Boxel; Heidi I L Jacobs; Benedikt A Poser; Kamil Uludag; Frans R J Verhey; Dimo Ivanov Journal: Brain Struct Funct Date: 2020-10-22 Impact factor: 3.270