Keita Matsuura1, Masayuki Maeda2, Ken-Ichi Tabei3, Maki Umino4, Hiroyuki Kajikawa5, Masayuki Satoh6, Hirotaka Kida6, Hidekazu Tomimoto7. 1. Department of Neurology, Graduate School of Medicine, Mie University, Mie 514-8507, Japan; Department of Neurology, Suzuka Kaisei Hospital, Mie 513-8505, Japan. Electronic address: matsuura@kaiseihp.com. 2. Department of Advanced Diagnostic Imaging, Graduate School of Medicine, Mie University, Mie 514-8507, Japan. 3. Department of Neurology, Graduate School of Medicine, Mie University, Mie 514-8507, Japan; Dementia Prevention and Therapeutics, Mie University, Mie 514-8507, Japan. 4. Department of Radiology, Graduate School of Medicine, Mie University, Mie 514-8507, Japan. 5. Department of Neurology, Suzuka Kaisei Hospital, Mie 513-8505, Japan. 6. Dementia Prevention and Therapeutics, Mie University, Mie 514-8507, Japan. 7. Department of Neurology, Graduate School of Medicine, Mie University, Mie 514-8507, Japan.
Abstract
PURPOSE: Neuromelanin-sensitive MR imaging (NMI) is an increasingly powerful tool for the diagnosis of Parkinson's disease (PD). This study was undertaken to evaluate longitudinal changes on NMI in PD patients. METHODS: We examined longitudinal changes on NMI in 14 PD patients. The area and contrast ratio (CR) of the substantia nigra pars compacta (SNc) were comparatively analyzed. RESULTS: The total area and CR of the SNc upon follow-up NMI were significantly smaller than those on initial NMI (from 33.5±18.9 pixels and 6.35±2.86% to 21.5±16.7 pixels and 4.19±2.11%; Wilcoxon signed-rank test, p<0.001 and p=0.022, respectively). The area and CR of the dominant side SNc upon initial NMI were significantly greater than those on follow-up NMI (from 15.3±9.1 pixels and 6.5±2.7% to 7.9±8.5 pixels and 3.7±2.9%; Wilcoxon signed-rank test, p=0.002 and p=0.007, respectively). On a case-by-case basis, the area of the SNc invariably decreased upon follow-up NMI in all patients. We further demonstrated that the total area and CR of the SNc negatively correlated with disease duration (Pearson correlation coefficient, r=-0.63, p<0.001 and r=-0.41, p=0.031, respectively). In area analyses, our results demonstrated very high intraclass correlation coefficients for both intra- and inter-rater reliability. CONCLUSION: NMI is a useful and reliable tool for detecting neuropathological changes over time in PD patients.
PURPOSE:Neuromelanin-sensitive MR imaging (NMI) is an increasingly powerful tool for the diagnosis of Parkinson's disease (PD). This study was undertaken to evaluate longitudinal changes on NMI in PDpatients. METHODS: We examined longitudinal changes on NMI in 14 PDpatients. The area and contrast ratio (CR) of the substantia nigra pars compacta (SNc) were comparatively analyzed. RESULTS: The total area and CR of the SNc upon follow-up NMI were significantly smaller than those on initial NMI (from 33.5±18.9 pixels and 6.35±2.86% to 21.5±16.7 pixels and 4.19±2.11%; Wilcoxon signed-rank test, p<0.001 and p=0.022, respectively). The area and CR of the dominant side SNc upon initial NMI were significantly greater than those on follow-up NMI (from 15.3±9.1 pixels and 6.5±2.7% to 7.9±8.5 pixels and 3.7±2.9%; Wilcoxon signed-rank test, p=0.002 and p=0.007, respectively). On a case-by-case basis, the area of the SNc invariably decreased upon follow-up NMI in all patients. We further demonstrated that the total area and CR of the SNc negatively correlated with disease duration (Pearson correlation coefficient, r=-0.63, p<0.001 and r=-0.41, p=0.031, respectively). In area analyses, our results demonstrated very high intraclass correlation coefficients for both intra- and inter-rater reliability. CONCLUSION: NMI is a useful and reliable tool for detecting neuropathological changes over time in PDpatients.
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