Jiwon Lee1, Hee-Pyoung Park2, Mu-Hui Jeong1, Hyun-Chang Kim3. 1. Department of Anesthesiology and Pain Medicine, Keimyung University Dongsan Medical Center, 56 Dalseung-ro, Joong-gu, Daegu, 41931, Republic of Korea. 2. Department of Anesthesiology and Pain Medicine, Seoul National University, Seoul, Republic of Korea. 3. Department of Anesthesiology and Pain Medicine, Keimyung University Dongsan Medical Center, 56 Dalseung-ro, Joong-gu, Daegu, 41931, Republic of Korea. onidori1979@gmail.com.
Abstract
PURPOSE:Postoperative sore throat (POST) after general anesthesia with endotracheal intubation is a common and undesirable complication. In this study, we evaluated the combined effects of paracetamol and dexamethasone on the prevention of POST in patients after general anesthesia. METHODS: A total of 226 patients scheduled for urologic surgery under general anesthesia were randomly assigned to one of two groups. In the DexaPara group (n = 113), dexamethasone (10 mg) and paracetamol (1000 mg) was infused. In the Dexa group (n = 113), dexamethasone (10 mg) alone was given. POST, hoarseness, and dysphagia were monitored. The postoperative wound pain score and perioperative opioid requirements were compared. In addition, complications related to opioids were compared between the groups. RESULTS: The overall incidence of POST was lower in the DexaPara group than in the Dexa group [42 (37%) vs. 72 (64%), p < 0.001]. The incidence of POST while resting at postoperative 1 and 6 h was lower in the DexaPara group than in the Dexa group (p = 0.008 and p = 0.004, respectively). The incidence of postoperative nausea, vomiting, drowsiness, shivering, and headache was comparable between the groups. CONCLUSIONS:Paracetamol and dexamethasone infusion reduced the incidence of POST without serious complications in patients for urologic surgery under general anesthesia.
RCT Entities:
PURPOSE: Postoperative sore throat (POST) after general anesthesia with endotracheal intubation is a common and undesirable complication. In this study, we evaluated the combined effects of paracetamol and dexamethasone on the prevention of POST in patients after general anesthesia. METHODS: A total of 226 patients scheduled for urologic surgery under general anesthesia were randomly assigned to one of two groups. In the DexaPara group (n = 113), dexamethasone (10 mg) and paracetamol (1000 mg) was infused. In the Dexa group (n = 113), dexamethasone (10 mg) alone was given. POST, hoarseness, and dysphagia were monitored. The postoperative wound pain score and perioperative opioid requirements were compared. In addition, complications related to opioids were compared between the groups. RESULTS: The overall incidence of POST was lower in the DexaPara group than in the Dexa group [42 (37%) vs. 72 (64%), p < 0.001]. The incidence of POST while resting at postoperative 1 and 6 h was lower in the DexaPara group than in the Dexa group (p = 0.008 and p = 0.004, respectively). The incidence of postoperative nausea, vomiting, drowsiness, shivering, and headache was comparable between the groups. CONCLUSIONS:Paracetamol and dexamethasone infusion reduced the incidence of POST without serious complications in patients for urologic surgery under general anesthesia.
Authors: X Combes; F Schauvliege; O Peyrouset; C Motamed; K Kirov; G Dhonneur; P Duvaldestin Journal: Anesthesiology Date: 2001-11 Impact factor: 7.892
Authors: Michael L Rasmussen; Ole Mathiesen; Gerd Dierking; Birgitte V Christensen; Karen L Hilsted; Tommy K Larsen; Joergen B Dahl Journal: Eur J Anaesthesiol Date: 2010-04 Impact factor: 4.330