O Canbay1, N Celebi, A Sahin, V Celiker, S Ozgen, U Aypar. 1. Faculty of Medicine, Department of Anaesthesiology, Hacettepe University, 06100 Sihhiye/Ankara, Turkey. ozgurcanbay@yahoo.com
Abstract
BACKGROUND:Tracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in postoperative sore throat (POST) with reported incidences of 21-65%. We compared the effectiveness of ketamine gargles with placebo in preventing POST after endotracheal intubation. METHODS:Forty-six, ASA I-II, patients undergoing elective surgery for septorhinoplasty under general anaesthesia were enrolled in this prospective, randomized, placebo-controlled, single-blind study. Patients were randomly allocated into two groups of 23 subjects each: Group C, saline 30 ml; Group K, ketamine 40 mg in saline 30 ml. Patients were asked to gargle this mixture for 30 s, 5 min before induction of anaesthesia. POST was graded at 0, 2, 4, and 24 h after operation on a four-point scale (0-3). RESULTS:POST occurred more frequently in Group C, when compared with Group K, at 0, 2, and 24 h and significantly more patients suffered severe POST in Group C at 4 and 24 h compared with Group K (P<0.05). CONCLUSIONS:Ketamine gargle significantly reduced the incidence and severity of POST.
RCT Entities:
BACKGROUND: Tracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in postoperative sore throat (POST) with reported incidences of 21-65%. We compared the effectiveness of ketamine gargles with placebo in preventing POST after endotracheal intubation. METHODS: Forty-six, ASA I-II, patients undergoing elective surgery for septorhinoplasty under general anaesthesia were enrolled in this prospective, randomized, placebo-controlled, single-blind study. Patients were randomly allocated into two groups of 23 subjects each: Group C, saline 30 ml; Group K, ketamine 40 mg in saline 30 ml. Patients were asked to gargle this mixture for 30 s, 5 min before induction of anaesthesia. POST was graded at 0, 2, 4, and 24 h after operation on a four-point scale (0-3). RESULTS: POST occurred more frequently in Group C, when compared with Group K, at 0, 2, and 24 h and significantly more patients suffered severe POST in Group C at 4 and 24 h compared with Group K (P<0.05). CONCLUSIONS:Ketamine gargle significantly reduced the incidence and severity of POST.
Authors: Sjaak Pouwels; Pieter S Stepaniak; Marc P Buise; R Arthur Bouwman; Simon W Nienhuijs Journal: Indian J Surg Date: 2016-10-19 Impact factor: 0.656
Authors: Sun Young Park; Sang Hyun Kim; Jung Il Noh; Su Myoung Lee; Mun Gyu Kim; Sang Ho Kim; Si Young Ok; Soon Im Kim Journal: Korean J Anesthesiol Date: 2010-07-21