| Literature DB >> 28973554 |
Joao Prola Netto1,2, Jeffrey Iliff3, Danica Stanimirovic4, Kenneth A Krohn5,6, Bronwyn Hamilton2, Csanad Varallyay1,6, Seymur Gahramanov7, Heike Daldrup-Link8, Christopher d'Esterre9, Berislav Zlokovic10, Haris Sair11, Yueh Lee12, Saeid Taheri13, Rajan Jain14, Ashok Panigrahy15, Daniel S Reich16, Lester R Drewes17, Mauricio Castillo12, Edward A Neuwelt1,18,19.
Abstract
Physiological and pathological processes that increase or decrease the central nervous system's need for nutrients and oxygen via changes in local blood supply act primarily at the level of the neurovascular unit (NVU). The NVU consists of endothelial cells, associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymal cells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essential for interpretation of central nervous system physiology and pathology as revealed by conventional and advanced imaging techniques. This article reviews current strategies for interrogating the NVU, focusing on vascular permeability, blood volume, and functional imaging, as assessed by ferumoxytol an iron oxide nanoparticle.Entities:
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Year: 2018 PMID： 28973554 PMCID： PMC6256943 DOI： 10.1093/neuros/nyx357
Source DB: PubMed Journal: Neurosurgery ISSN： 0148-396X Impact factor: 4.654