Domenico Zacà1, Jorge Jovicich, Sreenivasan R Nadar, James T Voyvodic, Jay J Pillai. 1. Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Center for Mind/Brain Sciences, University of Trento, Italy.
Abstract
PURPOSE: (i) to validate blood oxygenation level dependent (BOLD) breathhold cerebrovascular reactivity (BH CVR) mapping as an effective technique for potential detection of neurovascular uncoupling (NVU) in a cohort of patients with perirolandic low grade gliomas undergoing presurgical functional MRI (fMRI) for sensorimotor mapping, and (ii) to determine whether NVU potential, as assessed by BH CVR mapping, is prevalent in this tumor group. MATERIALS AND METHODS: We retrospectively evaluated 12 patients, with histological diagnosis of grade II glioma, who performed multiple motor tasks and a BH task. Sensorimotor activation maps and BH CVR maps were compared in two automatically defined regions of interest (ROIs), ipsilateral to the lesion (i.e., ipsilesional) and contralateral to the lesion (i.e., contralesional). RESULTS: Motor task mean T-value was significantly higher in the contralesional ROIs (6.00 ± 1.74 versus 4.34 ± 1.68; P = 0.00004) as well as the BH mean T-value (4.74 ± 2.30 versus 4.09 ± 2.50; P = 0.009). The number of active voxels was significantly higher in the contralesional ROIs (Z = 2.99; P = 0.03). Actual NVU prevalence was 75%. CONCLUSION: Presurgical sensorimotor fMRI mapping can be affected by NVU-related false negative activation in low grade gliomas (76% of analyzed tasks).
PURPOSE: (i) to validate blood oxygenation level dependent (BOLD) breathhold cerebrovascular reactivity (BH CVR) mapping as an effective technique for potential detection of neurovascular uncoupling (NVU) in a cohort of patients with perirolandic low grade gliomas undergoing presurgical functional MRI (fMRI) for sensorimotor mapping, and (ii) to determine whether NVU potential, as assessed by BH CVR mapping, is prevalent in this tumor group. MATERIALS AND METHODS: We retrospectively evaluated 12 patients, with histological diagnosis of grade II glioma, who performed multiple motor tasks and a BH task. Sensorimotor activation maps and BH CVR maps were compared in two automatically defined regions of interest (ROIs), ipsilateral to the lesion (i.e., ipsilesional) and contralateral to the lesion (i.e., contralesional). RESULTS: Motor task mean T-value was significantly higher in the contralesional ROIs (6.00 ± 1.74 versus 4.34 ± 1.68; P = 0.00004) as well as the BH mean T-value (4.74 ± 2.30 versus 4.09 ± 2.50; P = 0.009). The number of active voxels was significantly higher in the contralesional ROIs (Z = 2.99; P = 0.03). Actual NVU prevalence was 75%. CONCLUSION: Presurgical sensorimotor fMRI mapping can be affected by NVU-related false negative activation in low grade gliomas (76% of analyzed tasks).
Authors: A Vesely; H Sasano; G Volgyesi; R Somogyi; J Tesler; L Fedorko; J Grynspan; A Crawley; J A Fisher; D Mikulis Journal: Magn Reson Med Date: 2001-06 Impact factor: 4.668
Authors: John L Ulmer; Hendrikus G Krouwer; Wade M Mueller; M Sahin Ugurel; Mehmet Kocak; Leighton P Mark Journal: AJNR Am J Neuroradiol Date: 2003-02 Impact factor: 3.825
Authors: Shruti Agarwal; Haris I Sair; Raag Airan; Jun Hua; Craig K Jones; Hye-Young Heo; Alessandro Olivi; Martin A Lindquist; James J Pekar; Jay J Pillai Journal: Brain Connect Date: 2016-02-26
Authors: Anthony J Tyndall; Julia Reinhardt; Volker Tronnier; Luigi Mariani; Christoph Stippich Journal: Eur Radiol Date: 2016-05-19 Impact factor: 5.315
Authors: Herie Sun; Behroze Vachha; Maria E Laino; Mehrnaz Jenabi; Jessica R Flynn; Zhigang Zhang; Andrei I Holodny; Kyung K Peck Journal: Radiology Date: 2020-01-14 Impact factor: 11.105
Authors: S G Bowden; B J A Gill; Z K Englander; C I Horenstein; G Zanazzi; P D Chang; J Samanamud; A Lignelli; J N Bruce; P Canoll; J Grinband Journal: AJNR Am J Neuroradiol Date: 2018-01-25 Impact factor: 3.825
Authors: Amir Iranmahboob; Kyung K Peck; Nicole P Brennan; Sasan Karimi; Ryan Fisicaro; Bob Hou; Andrei I Holodny Journal: J Neuroimaging Date: 2016 Mar-Apr Impact factor: 2.486