Literature DB >> 28971871

New Variant of mcr-3 in an Extensively Drug-Resistant Escherichia coli Clinical Isolate Carrying mcr-1 and blaNDM-5.

Lu Liu1,2, Yu Feng1,2, Xiaoxia Zhang1,2, Alan McNally3, Zhiyong Zong4,2,5,6.   

Abstract

A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly identified mcr-3, and a carbapenemase gene, blaNDM-5mcr-3 is a new variant (mcr-3.5) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by a TnAs3-like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that mcr-3 may have widely spread.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Enterobacteriaceae; Escherichia coli; colistin; plasmids; resistance

Mesh：

Substances：

Year:  2017        PMID： 28971871      PMCID： PMC5700326          DOI： 10.1128/AAC.01757-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Rapid and simple determination of the Escherichia coli phylogenetic group.

Authors:  O Clermont; S Bonacorsi; E Bingen
Journal:  Appl Environ Microbiol       Date:  2000-10       Impact factor: 4.792

2.  A novel variant, NDM-5, of the New Delhi metallo-β-lactamase in a multidrug-resistant Escherichia coli ST648 isolate recovered from a patient in the United Kingdom.

Authors:  Michael Hornsey; Lynette Phee; David W Wareham
Journal:  Antimicrob Agents Chemother       Date:  2011-09-19       Impact factor: 5.191

3.  Autonomous and non-autonomous Tn3-family transposons and their role in the evolution of mobile genetic elements.

Authors:  Magdalena Szuplewska; Jakub Czarnecki; Dariusz Bartosik
Journal:  Mob Genet Elements       Date:  2015-02-03

4.  IncP Plasmid Carrying Colistin Resistance Gene mcr-1 in Klebsiella pneumoniae from Hospital Sewage.

Authors:  Feifei Zhao; Yu Feng; Xiaoju Lü; Alan McNally; Zhiyong Zong
Journal:  Antimicrob Agents Chemother       Date:  2017-01-24       Impact factor: 5.191

5.  Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016.

Authors:  Basil Britto Xavier; Christine Lammens; Rohit Ruhal; Samir Kumar-Singh; Patrick Butaye; Herman Goossens; Surbhi Malhotra-Kumar
Journal:  Euro Surveill       Date:  2016-07-07

6.  blaNDM-5 carried by an IncX3 plasmid in Escherichia coli sequence type 167.

Authors:  Ping Yang; Yi Xie; Ping Feng; Zhiyong Zong
Journal:  Antimicrob Agents Chemother       Date:  2014-09-22       Impact factor: 5.191

7.  Mortality and hospital stay associated with resistant Staphylococcus aureus and Escherichia coli bacteremia: estimating the burden of antibiotic resistance in Europe.

Authors:  Marlieke E A de Kraker; Peter G Davey; Hajo Grundmann
Journal:  PLoS Med       Date:  2011-10-11       Impact factor: 11.069

8.  Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli.

Authors:  Wenjuan Yin; Hui Li; Yingbo Shen; Zhihai Liu; Shaolin Wang; Zhangqi Shen; Rong Zhang; Timothy R Walsh; Jianzhong Shen; Yang Wang
Journal:  mBio       Date:  2017-06-27       Impact factor: 7.867

9.  Identification of a novel transposon-associated phosphoethanolamine transferase gene, mcr-5, conferring colistin resistance in d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi B.

Authors:  Maria Borowiak; Jennie Fischer; Jens A Hammerl; Rene S Hendriksen; Istvan Szabo; Burkhard Malorny
Journal:  J Antimicrob Chemother       Date:  2017-12-01       Impact factor: 5.790

10.  Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15.

Authors:  Teresa M Coque; Angela Novais; Alessandra Carattoli; Laurent Poirel; Johann Pitout; Luísa Peixe; Fernando Baquero; Rafael Cantón; Patrice Nordmann
Journal:  Emerg Infect Dis       Date:  2008-02       Impact factor: 6.883
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  26 in total

1.  Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes.

Authors:  Sally R Partridge; Vincenzo Di Pilato; Yohei Doi; Michael Feldgarden; Daniel H Haft; William Klimke; Samir Kumar-Singh; Jian-Hua Liu; Surbhi Malhotra-Kumar; Arjun Prasad; Gian Maria Rossolini; Stefan Schwarz; Jianzhong Shen; Timothy Walsh; Yang Wang; Basil Britto Xavier
Journal:  J Antimicrob Chemother       Date:  2018-10-01       Impact factor: 5.790

Review 2.  The rise and spread of mcr plasmid-mediated polymyxin resistance.

Authors:  Sue C Nang; Jian Li; Tony Velkov
Journal:  Crit Rev Microbiol       Date:  2019-05-23       Impact factor: 7.624

3.  Coexistence of Two blaNDM-5 Genes on an IncF Plasmid as Revealed by Nanopore Sequencing.

Authors:  Yu Feng; Lu Liu; Alan McNally; Zhiyong Zong
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

4.  A novel plasmid-encoded mcr-4.3 gene in a colistin-resistant Acinetobacter baumannii clinical strain.

Authors:  Natacha Martins-Sorenson; Erik Snesrud; Danilo Elias Xavier; Luciana Camila Cacci; Anthony T Iavarone; Patrick McGann; Lee W Riley; Beatriz Meurer Moreira
Journal:  J Antimicrob Chemother       Date:  2020-01-01       Impact factor: 5.790

5.  Mechanistic insights into transferable polymyxin resistance among gut bacteria.

Authors:  Yongchang Xu; Jingxia Lin; Tao Cui; Swaminath Srinivas; Youjun Feng
Journal:  J Biol Chem       Date:  2018-02-09       Impact factor: 5.157

6.  Molecular Insights into Functional Differences between mcr-3- and mcr-1-Mediated Colistin Resistance.

Authors:  Hui Li; Lu Yang; Zhihai Liu; Wenjuan Yin; Dejun Liu; Yingbo Shen; Timothy Walsh; Bing Shao; Yang Wang
Journal:  Antimicrob Agents Chemother       Date:  2018-08-27       Impact factor: 5.191

Review 7.  Mobilized colistin resistance (mcr) genes from 1 to 10: a comprehensive review.

Authors:  Nadheema Hammood Hussein; Israa M S Al-Kadmy; Butheina Mohammed Taha; Jumaah Dakel Hussein
Journal:  Mol Biol Rep       Date:  2021-04-10       Impact factor: 2.316

8.  Genetic and Functional Characterization of an MCR-3-Like Enzyme-Producing Escherichia coli Isolate Recovered from Swine in Brazil.

Authors:  Nicolas Kieffer; Patrice Nordmann; Andrea Micke Moreno; Luisa Zanolli Moreno; Richard Chaby; Aude Breton; Pierre Tissières; Laurent Poirel
Journal:  Antimicrob Agents Chemother       Date:  2018-06-26       Impact factor: 5.191

9.  Potential transferability of mcr-3 via IS26-mediated homologous recombination in Escherichia coli.

Authors:  Zheng Wang; Yulin Fu; Xiang-Dang Du; Haiyang Jiang; Yang Wang
Journal:  Emerg Microbes Infect       Date:  2018-04-04       Impact factor: 7.163

10.  Alkaline Peptone Water-Based Enrichment Method for mcr-3 From Acute Diarrheic Outpatient Gut Samples.

Authors:  Qiaoling Sun; Yanyan Hu; Hongwei Zhou; Lingbin Shu; Hanyu Wang; Zixian Huang; Rong Zhang
Journal:  Front Med (Lausanne)       Date:  2018-05-03
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