Literature DB >> 28960222

Impact of cellular health conditions on the protein folding state in mammalian cells.

Kohsuke Inomata1, Hajime Kamoshida2, Masaomi Ikari3, Yutaka Ito2, Takanori Kigawa4.   

Abstract

By using in-cell NMR experiments, we have demonstrated that the protein folding state in cells is significantly influenced by the cellular health conditions. hAK1 was denatured in cells under stressful culture conditions, while it remained functional and properly folded in cells continuously supplied with a fresh medium.

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Year:  2017        PMID： 28960222     DOI： 10.1039/c7cc06004a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

1.  Improved sensitivity and resolution of in-cell NMR spectra.

Authors:  David S Burz; Leonard Breindel; Alexander Shekhtman
Journal:  Methods Enzymol       Date:  2019-03-13       Impact factor: 1.600

2.  Potent Inhibitors of Mycobacterium tuberculosis Growth Identified by Using in-Cell NMR-based Screening.

Authors:  Christopher M DeMott; Roxie Girardin; Jacqueline Cobbert; Sergey Reverdatto; David S Burz; Kathleen McDonough; Alexander Shekhtman
Journal:  ACS Chem Biol       Date:  2018-02-02       Impact factor: 5.100

3.  Real-Time In-Cell Nuclear Magnetic Resonance: Ribosome-Targeted Antibiotics Modulate Quinary Protein Interactions.

Authors:  Leonard Breindel; Christopher DeMott; David S Burz; Alexander Shekhtman
Journal:  Biochemistry       Date:  2018-01-08       Impact factor: 3.162

4.  Molecular mechanism of glycolytic flux control intrinsic to human phosphoglycerate kinase.

Authors:  Hiromasa Yagi; Takuma Kasai; Elisa Rioual; Teppei Ikeya; Takanori Kigawa
Journal:  Proc Natl Acad Sci U S A       Date:  2021-12-14       Impact factor: 12.779

Review 5.  In-Cell NMR Spectroscopy of Intrinsically Disordered Proteins.

Authors:  Nicholas Sciolino; David S Burz; Alexander Shekhtman
Journal:  Proteomics       Date:  2019-01-15       Impact factor: 3.984

Review 6.  Radio Signals from Live Cells: The Coming of Age of In-Cell Solution NMR.

Authors:  Enrico Luchinat; Matteo Cremonini; Lucia Banci
Journal:  Chem Rev       Date:  2022-01-21       Impact factor: 72.087

7.  NMR Characterization of Surface Receptor Protein Interactions in Live Cells Using Methylcellulose Hydrogels.

Authors:  Borja Mateos; Marco Sealey-Cardona; Katja Balazs; Judith Konrat; Guenther Staffler; Robert Konrat
Journal:  Angew Chem Int Ed Engl       Date:  2020-01-29       Impact factor: 15.336

8.  Microfluidics delivery of DARPP-32 into HeLa cells maintains viability for in-cell NMR spectroscopy.

Authors:  Nicholas Sciolino; Anna Liu; Leonard Breindel; David S Burz; Todd Sulchek; Alexander Shekhtman
Journal:  Commun Biol       Date:  2022-05-12

9.  Towards Profiling of the G-Quadruplex Targeting Drugs in the Living Human Cells Using NMR Spectroscopy.

Authors:  Daniel Krafčík; Eva Ištvánková; Šimon Džatko; Pavlína Víšková; Silvie Foldynová-Trantírková; Lukáš Trantírek
Journal:  Int J Mol Sci       Date:  2021-06-03       Impact factor: 5.923

10.  Connecting Longitudinal and Transverse Relaxation Rates in Live-Cell NMR.

Authors:  Sarah Leeb; Fan Yang; Mikael Oliveberg; Jens Danielsson
Journal:  J Phys Chem B       Date:  2020-11-12       Impact factor: 2.991
  10 in total

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