| Literature DB >> 28951605 |
Yuezhou Wang1,2, Yue Wang1,2, An-An Wu3, Lei Zhang1,2, Zhiyu Hu1,2, Huiying Huang1,2, Qingyan Xu1,2, Xianming Deng1,2.
Abstract
Four new 12,8-Eudesmanolides (1-4) and one known compound 5 named 13-Hydroxy-3,7(11)-eudesmadien-12,8-olide, were isolated from a mangrove rhizosphere-derived fungus Eutypella sp. 1-15. Their structures with absolute stereochemistry were determined by the comprehensive spectroscopic data, experimental and calculated ECD analysis. Compound 1 exhibited potent anticancer activity against JEKO-1 and HepG2 with IC50 values of 8.4 and 28.5 μM, respectively. Additionally, compound 1 also showed moderate antimicrobial activity.Entities:
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Year: 2017 PMID： 28951605 DOI： 10.1038/ja.2017.89
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649