Scott H Robertson1,2, Rohan S Virgincar1,3, Elianna A Bier1,2, Mu He1,4, Geoffrey M Schrank1, Rose Marie Smigla5, Craig Rackley6, H Page McAdams6, Bastiaan Driehuys1,2,3,6. 1. Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, USA. 2. Medical Physics Graduate Program, Duke University, Durham, North Carolina, USA. 3. Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. 4. Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, USA. 5. Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. 6. Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA.
Abstract
PURPOSE: The purpose of this work was to accurately characterize the spectral properties of hyperpolarized 129 Xe in patients with idiopathic pulmonary fibrosis (IPF) compared to healthy volunteers. METHODS: Subjects underwent hyperpolarized 129 Xe breath-hold spectroscopy, during which 38 dissolved-phase free induction decays (FIDs) were acquired after reaching steady state (echo time/repetition time = 0.875/50 ms; bandwidth = 8.06 kHz; flip angle≈22 °). FIDs were averaged and then decomposed into multiple spectral components using time-domain curve fitting. The resulting amplitudes, frequencies, line widths, and starting phases of each component were compared among groups using a Mann-Whitney-Wilcoxon U test. RESULTS: Three dissolved-phase resonances, consisting of red blood cells (RBCs) and two barrier compartments, were consistently identified in all subjects. In subjects with IPF relative to healthy volunteers, the RBC frequency was 0.70 parts per million (ppm) more negative (P = 0.05), the chemical shift of barrier 2 was 0.6 ppm more negative (P = 0.009), the line widths of both barrier peaks were ∼2 ppm narrower (P < 0.001), and the starting phase of barrier 1 was 20.3 ° higher (P = 0.01). Moreover, the ratio RBC:barriers was reduced by 52.9% in IPF (P < 0.001). CONCLUSIONS: The accurate decomposition of 129 Xe spectra not only has merit for developing a global metric of pulmonary function, but also provides necessary insights to optimize phase-sensitive methods for imaging 129 Xe gas transfer. Magn Reson Med 78:1306-1315, 2017.
PURPOSE: The purpose of this work was to accurately characterize the spectral properties of hyperpolarized 129 Xe in patients with idiopathic pulmonary fibrosis (IPF) compared to healthy volunteers. METHODS: Subjects underwent hyperpolarized 129 Xe breath-hold spectroscopy, during which 38 dissolved-phase free induction decays (FIDs) were acquired after reaching steady state (echo time/repetition time = 0.875/50 ms; bandwidth = 8.06 kHz; flip angle≈22 °). FIDs were averaged and then decomposed into multiple spectral components using time-domain curve fitting. The resulting amplitudes, frequencies, line widths, and starting phases of each component were compared among groups using a Mann-Whitney-Wilcoxon U test. RESULTS: Three dissolved-phase resonances, consisting of red blood cells (RBCs) and two barrier compartments, were consistently identified in all subjects. In subjects with IPF relative to healthy volunteers, the RBC frequency was 0.70 parts per million (ppm) more negative (P = 0.05), the chemical shift of barrier 2 was 0.6 ppm more negative (P = 0.009), the line widths of both barrier peaks were ∼2 ppm narrower (P < 0.001), and the starting phase of barrier 1 was 20.3 ° higher (P = 0.01). Moreover, the ratio RBC:barriers was reduced by 52.9% in IPF (P < 0.001). CONCLUSIONS: The accurate decomposition of 129 Xe spectra not only has merit for developing a global metric of pulmonary function, but also provides necessary insights to optimize phase-sensitive methods for imaging 129 Xe gas transfer. Magn Reson Med 78:1306-1315, 2017.
Authors: Rosa Tamara Branca; Ting He; Le Zhang; Carlos S Floyd; Matthew Freeman; Christian White; Alex Burant Journal: Proc Natl Acad Sci U S A Date: 2014-12-01 Impact factor: 11.205
Authors: Kun Qing; Kai Ruppert; Yun Jiang; Jaime F Mata; G Wilson Miller; Y Michael Shim; Chengbo Wang; Iulian C Ruset; F William Hersman; Talissa A Altes; John P Mugler Journal: J Magn Reson Imaging Date: 2013-05-16 Impact factor: 4.813
Authors: Samuel Patz; Iga Muradian; Mirko I Hrovat; Iulian C Ruset; George Topulos; Silviu D Covrig; Eric Frederick; Hiroto Hatabu; F W Hersman; James P Butler Journal: Acad Radiol Date: 2008-06 Impact factor: 3.173
Authors: S Sivaram Kaushik; Scott H Robertson; Matthew S Freeman; Mu He; Kevin T Kelly; Justus E Roos; Craig R Rackley; W Michael Foster; H Page McAdams; Bastiaan Driehuys Journal: Magn Reson Med Date: 2015-05-18 Impact factor: 4.668
Authors: Zackary I Cleveland; Gary P Cofer; Gregory Metz; Denise Beaver; John Nouls; S Sivaram Kaushik; Monica Kraft; Jan Wolber; Kevin T Kelly; H Page McAdams; Bastiaan Driehuys Journal: PLoS One Date: 2010-08-16 Impact factor: 3.240
Authors: Jeff Kammerman; Andrew D Hahn; Robert V Cadman; Annelise Malkus; David Mummy; Sean B Fain Journal: Magn Reson Med Date: 2020-03-11 Impact factor: 4.668
Authors: Kai Ruppert; Faraz Amzajerdian; Hooman Hamedani; Yi Xin; Luis Loza; Tahmina Achekzai; Ian F Duncan; Harrilla Profka; Sarmad Siddiqui; Mehrdad Pourfathi; Maurizio F Cereda; Stephen Kadlecek; Rahim R Rizi Journal: Magn Reson Med Date: 2018-04-22 Impact factor: 4.668
Authors: Elianna A Bier; John C Nouls; Ziyi Wang; Mu He; Geoff Schrank; Naomi Morales-Medina; Ralph Hashoian; Harvey Svetlik; John P Mugler; Bastiaan Driehuys Journal: Magn Reson Med Date: 2019-06-19 Impact factor: 4.668
Authors: Elianna A Bier; Scott H Robertson; Geoffry M Schrank; Craig Rackley; Joseph G Mammarappallil; Sudarshan Rajagopal; H Page McAdams; Bastiaan Driehuys Journal: NMR Biomed Date: 2018-11-20 Impact factor: 4.044