Literature DB >> 2893419

Postsynaptic dopamine (DA) receptor stimulator properties of the putative DA autoreceptor-selective agonist B-HT 920 uncovered by co-treatment with the D-1 agonist SK&F 38393.

S Hjorth1, A Carlsson.   

Abstract

Postsynaptic dopaminergic behavioural effects of D-2 agonists can be promoted by concomitant D-1 receptor activation. The present experiment explored whether such effects could be elicited by the putative autoreceptor-selective D-2 agonist B-HT 920, when combined with the D-1 agonist SK&F 38393. Except for occasional jerks induced by B-HT 920, neither agonist caused significant dopaminergic stimulation when given separately, whereas combined treatment with SK&F 38393 and B-HT 920 induced clear-cut motor activation--particularly focused stereotyped licking and sniffing--in reserpine/AMT-pretreated rats. Both the D-1 antagonist SCH 23390 and the D-2 antagonist spiperone abolished these effects, while the SK&F/B-HT-induced stimulation was not significantly affected by the alpha 2-blocker idazoxan. It appears that classical postsynaptic DA receptor-stimulatory properties of B-HT 920 can indeed be demonstrated, provided that sufficient D-1 receptor tone prevails.

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Year:  1987        PMID： 2893419     DOI： 10.1007/bf00207249

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  9 in total

1.  Obligatory D-1/D-2 receptor interaction in the generation of dopamine agonist related behaviors.

Authors:  A R Braun; T N Chase
Journal:  Eur J Pharmacol       Date:  1986-11-19       Impact factor: 4.432

2.  Stimulation of postsynaptic DA2 receptors produces jerks in reserpine-treated rats.

Authors:  M Grabowska-Andén; N E Andén
Journal:  J Pharm Pharmacol       Date:  1983-08       Impact factor: 3.765

3.  Effects of B-HT 920 and B-HT 933 on dopamine and noradrenaline autoreceptors in the rat brain.

Authors:  N E Andén; H Nilsson; E Ros; U Thornström
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1983-01

Review 4.  Two dopamine receptors: biochemistry, physiology and pharmacology.

Authors:  J C Stoof; J W Kebabian
Journal:  Life Sci       Date:  1984-12-03       Impact factor: 5.037

Review 5.  Dopamine receptor agonists: mechanisms underlying autoreceptor selectivity. II. Theoretical considerations.

Authors:  D Clark; S Hjorth; A Carlsson
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575

6.  The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment.

Authors:  D Hinzen; O Hornykiewicz; W Kobinger; L Pichler; C Pifl; G Schingnitz
Journal:  Eur J Pharmacol       Date:  1986-11-12       Impact factor: 4.432

7.  Behavioural stimulation is induced by separate dopamine D-1 and D-2 receptor sites in reserpine-pretreated but not in normal rats.

Authors:  J Arnt
Journal:  Eur J Pharmacol       Date:  1985-07-11       Impact factor: 4.432

8.  The central effects of a novel dopamine agonist.

Authors:  P E Setler; H M Sarau; C L Zirkle; H L Saunders
Journal:  Eur J Pharmacol       Date:  1978-08-15       Impact factor: 4.432

9.  Evidence for a specific effect of BHT 920, an azepine derivative, on tyrosine hydroxylase in the dopaminergic system of the rat.

Authors:  H M Jennewein; E A Bruckwick; I Hanbauer; J Mierau; W Lovenberg
Journal:  Eur J Pharmacol       Date:  1986-04-29       Impact factor: 4.432
  9 in total
  17 in total

1.  B-HT 920 is a full agonist at both pre- and postsynaptic D-2 dopamine receptors.

Authors:  N E Andén; M Grabowska-Andén
Journal:  J Neural Transm Gen Sect       Date:  1990

Review 2.  Effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system.

Authors:  G B Baker; A J Greenshaw
Journal:  Cell Mol Neurobiol       Date:  1989-03       Impact factor: 5.046

3.  Studies on the effect of MDMA ('ecstasy') on the body temperature of rats housed at different ambient room temperatures.

Authors:  A Richard Green; Esther O'Shea; Kathryn S Saadat; J Martin Elliott; M Isabel Colado
Journal:  Br J Pharmacol       Date:  2005-09       Impact factor: 8.739

4.  Dopamine D-2 receptor agonist-induced behavioural depression: critical dependence upon postsynaptic dopamine D-1 function. A behavioural and biochemical study.

Authors:  D M Jackson; S B Ross; L G Larsson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-10       Impact factor: 3.000

5.  Occurrence of yawning and decrease of prolactin levels via stimulation of dopamine D2-receptors after administration of SND 919 in rats.

Authors:  S Matsumoto; K Yamada; M Nagashima; M Domae; K Shirakawa; T Furukawa
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-07       Impact factor: 3.000

6.  Involvement of central beta-adrenoceptors in the regulation of yawning responses.

Authors:  K Yamada; S Matsumoto; M Nagashima; M Kumagai; H Kimura; T Furukawa
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-07       Impact factor: 3.000

Review 7.  The role of monoamines in the changes in body temperature induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and its derivatives.

Authors:  J R Docherty; A R Green
Journal:  Br J Pharmacol       Date:  2010-07       Impact factor: 8.739

8.  Evidence for postsynaptic dopamine agonist effects of B-HT 920 in the presence of the dopamine D-1 agonist SKF 38393.

Authors:  L T Meltzer; J N Wiley; A E Williams; T G Heffner
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

9.  Effects of the partial dopamine receptor agonists SDZ 208-911, SDZ 208-912 and terguride on central monoamine receptors. A behavioral, biochemical and electrophysiological study.

Authors:  K Svensson; A Ekman; M F Piercey; W E Hoffmann; J T Lum; A Carlsson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-09       Impact factor: 3.000

10.  In vivo dopamine (DA) receptor binding and behavioural effects of the putative DA autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 in rats with a unilateral nigral 6-OH-DA lesion.

Authors:  M Hajos; S Hjorth; K Svensson; A Carlsson
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972
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