Literature DB >> 6301216

Effects of B-HT 920 and B-HT 933 on dopamine and noradrenaline autoreceptors in the rat brain.

N E Andén, H Nilsson, E Ros, U Thornström.   

Abstract

B-HT 920 at low doses inhibited the accumulation of DOPA following treatment with reserpine and a DOPA decarboxylase inhibitor in the dopamine-, but not in the noradrenaline-predominant regions of the rat brain. B-HT 933 selectively inhibited this DOPA accumulation in the noradrenaline-predominant regions. These effects of B-HT 920 and B-HT 933 were completely antagonized by haloperidol and yohimbine, respectively. The rat motor activity was reduced by B-HT 920 and it was restored following apomorphine. B-HT 933 decreased the motor activity by a yohimbine-sensitive mechanism. The results indicate that B-HT 920 can selectively and potently stimulate the dopamine autoreceptors whereas B-HT 933 can selectively stimulate the noradrenaline autoreceptors.

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Year:  1983        PMID： 6301216     DOI： 10.1111/j.1600-0773.1983.tb01075.x

Source DB:  PubMed          Journal:  Acta Pharmacol Toxicol (Copenh)        ISSN： 0001-6683


  25 in total

1.  B-HT 920 is a full agonist at both pre- and postsynaptic D-2 dopamine receptors.

Authors:  N E Andén; M Grabowska-Andén
Journal:  J Neural Transm Gen Sect       Date:  1990

2.  Dopamine D-2 receptor agonist-induced behavioural depression: critical dependence upon postsynaptic dopamine D-1 function. A behavioural and biochemical study.

Authors:  D M Jackson; S B Ross; L G Larsson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-10       Impact factor: 3.000

3.  Occurrence of yawning and decrease of prolactin levels via stimulation of dopamine D2-receptors after administration of SND 919 in rats.

Authors:  S Matsumoto; K Yamada; M Nagashima; M Domae; K Shirakawa; T Furukawa
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-07       Impact factor: 3.000

4.  Effects of B-HT 920 on nigrostriatal and mesolimbic dopamine systems in normosensitive and supersensitive rats.

Authors:  P B Clarke; K J Wyder; A Jakubovic; H C Fibiger
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

Review 5.  Dopamine-receptor agonists: mechanisms underlying autoreceptor selectivity. I. Review of the evidence.

Authors:  D Clark; S Hjorth; A Carlsson
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575

6.  Demonstration of autoreceptors on dopamine neurons in different brain regions of rats treated with gammabutyrolactone.

Authors:  N E Andén; M Grabowska-Andén; B Liljenberg
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575

7.  Central dopaminergic properties of HW-165 and its enantiomers; trans-octahydrobenzo(f)quinoline congeners of 3-PPP.

Authors:  S Hjorth; K Svensson; A Carlsson; H Wikström; B Andersson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-07       Impact factor: 3.000

8.  The 5-HT1A receptor antagonist (S)-UH-301 decreases dopamine release in the rat nucleus accumbens and striatum.

Authors:  G G Nomikos; L Arborelius; B B Höök; U Hacksell; T H Svensson
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

9.  Hypotensive and bradycardic effects of talipexole (B-HT 920) in anaesthetized rabbits are antagonized by metoclopramide but not by yohimbine.

Authors:  R Palluk; J C Schilling; K Stockhaus; H Peil
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-07       Impact factor: 3.000

10.  Inhibitory dopamine receptors on sympathetic neurons innervating the cardiovascular system of the pithed rat. Characterization and role in relation to presynaptic alpha 2-adrenoceptors.

Authors:  B Wilffert; G Smit; A de Jonge; M J Thoolen; P B Timmermans; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-06       Impact factor: 3.000
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