Literature DB >> 2136999

B-HT 920 is a full agonist at both pre- and postsynaptic D-2 dopamine receptors.

N E Andén1, M Grabowska-Andén.   

Abstract

Stimulation of presynaptic D-2 dopamine receptors by B-HT 920 or by apomorphine inhibited the synthesis of dopamine in the corpus striatum of gammabutyrolactone-treated mice to about the same extent. Stimulation of postsynaptic D-2 dopamine receptors by B-HT 920 given in combination with the D-1 receptor agonist SKF38393 enhanced the motor activity of reserpine-treated mice at least as much as observed following the combined D-1/D-2 receptor agonist apomorphine. Since B-HT 920 is as effective as apomorphine in these models, B-HT 920 appears to be a full agonist at both pre- and post-synaptic D-2 dopamine receptors.

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Year:  1990        PMID： 2136999     DOI： 10.1007/bf01245131

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  18 in total

1.  Postsynaptic dopamine agonist properties of B-HT 920 as revealed by concomitant D-1 receptor stimulation.

Authors:  C Pifl; O Hornykiewicz
Journal:  Eur J Pharmacol       Date:  1988-01-27       Impact factor: 4.432

2.  The inhibition of catecholamine biosynthesis by apomorphine.

Authors:  M Goldstein; L S Freedman; T Backstrom
Journal:  J Pharm Pharmacol       Date:  1970-09       Impact factor: 3.765

3.  Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity.

Authors:  W Kehr; A Carlsson; M Lindqvist; T Magnusson; C Atack
Journal:  J Pharm Pharmacol       Date:  1972-09       Impact factor: 3.765

4.  Thyroxine and brain catecholamines: increased transmitter synthesis and increased receptor sensitivity.

Authors:  G Engström; T H Svensson; B Waldeck
Journal:  Brain Res       Date:  1974-09-13       Impact factor: 3.252

5.  Dopamine and noradrenaline receptor stimulation: reversal of reserpine-induced suppression of motor activity.

Authors:  N E Andén; U Strömbom; T H Svensson
Journal:  Psychopharmacologia       Date:  1973

6.  Determination of catecholamines in rat brain parts by reverse-phase ion-pair liquid chromatography.

Authors:  L J Felice; J D Felice; P T Kissinger
Journal:  J Neurochem       Date:  1978-12       Impact factor: 5.372

7.  Increased motor activity following combined stimulation of B-HT 920-sensitive and D-1 dopamine receptors.

Authors:  N E Andén; M Grabowska-Andén
Journal:  Acta Physiol Scand       Date:  1987-09

8.  Selective stimulation of dopamine and noradrenaline autoreceptors by B-HT 920 and B-HT 933, respectively.

Authors:  N E Andén; K Gołembiowska-Nikitin; U Thornström
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-11       Impact factor: 3.000

9.  Effects of B-HT 920 and B-HT 933 on dopamine and noradrenaline autoreceptors in the rat brain.

Authors:  N E Andén; H Nilsson; E Ros; U Thornström
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1983-01

10.  Dopamine autoreceptors and the effects of drugs on locomotion and dopamine synthesis.

Authors:  F Brown; W Campbell; P J Mitchell; K Randall
Journal:  Br J Pharmacol       Date:  1985-04       Impact factor: 8.739
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  5 in total

1.  Effects of the partial dopamine receptor agonists SDZ 208-911, SDZ 208-912 and terguride on central monoamine receptors. A behavioral, biochemical and electrophysiological study.

Authors:  K Svensson; A Ekman; M F Piercey; W E Hoffmann; J T Lum; A Carlsson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-09       Impact factor: 3.000

2.  Dopamine receptors, controlling dopamine levels in rat adrenal glands-comparison with central dopaminergic autoreceptors.

Authors:  M Kujacic; K Svensson; L Löfberg; A Carlsson
Journal:  J Neural Transm Gen Sect       Date:  1991

3.  Hypotensive and bradycardic effects of talipexole (B-HT 920) in anaesthetized rabbits are antagonized by metoclopramide but not by yohimbine.

Authors:  R Palluk; J C Schilling; K Stockhaus; H Peil
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-07       Impact factor: 3.000

4.  Dopamine D2 autoreceptors in rats are behaviorally functional at 21 but not 10 days of age.

Authors:  M Y Lin; D E Walters
Journal:  Psychopharmacology (Berl)       Date:  1994-03       Impact factor: 4.530

5.  Effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline on the prolactin suppression induced by a series of full and partial dopamine D2 receptor agonists in male rats.

Authors:  A Ekman; E Eriksson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-08       Impact factor: 3.000
  5 in total

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