BACKGROUND: Optical coherence tomography (OCT) angiography is a new method to assess the density of the vascular networks. Vascular abnormalities are considered involved in multiple sclerosis (MS) pathology. OBJECTIVE: To assess the presence of vascular abnormalities in MS and to evaluate their correlation to disease features. METHODS: A total of 50 MS patients with and without history of optic neuritis (ON) and 46 healthy subjects were included. All underwent spectral domain (SD)-OCT and OCT angiography. Clinical history, Expanded Disability Status Scale (EDSS), Multiple Sclerosis Severity Score (MSSS) and disease duration were collected. RESULTS: Angio-OCT showed a vessel density reduction in eyes of MS patients when compared to controls. A statistically significant reduction in all SD-OCT and OCT angiography parameters was noticed both in eyes with and without ON when compared with control eyes. We found an inverse correlation between SD-OCT parameters and MSSS ( p = 0.003) and between vessel density parameters and EDSS ( p = 0.007). CONCLUSION: We report a vessel density reduction in retina of MS patients. We highlight the clinical correlation between vessel density and EDSS, suggesting that angio-OCT could be a good marker of disease and of disability in MS.
BACKGROUND: Optical coherence tomography (OCT) angiography is a new method to assess the density of the vascular networks. Vascular abnormalities are considered involved in multiple sclerosis (MS) pathology. OBJECTIVE: To assess the presence of vascular abnormalities in MS and to evaluate their correlation to disease features. METHODS: A total of 50 MSpatients with and without history of optic neuritis (ON) and 46 healthy subjects were included. All underwent spectral domain (SD)-OCT and OCT angiography. Clinical history, Expanded Disability Status Scale (EDSS), Multiple Sclerosis Severity Score (MSSS) and disease duration were collected. RESULTS: Angio-OCT showed a vessel density reduction in eyes of MSpatients when compared to controls. A statistically significant reduction in all SD-OCT and OCT angiography parameters was noticed both in eyes with and without ON when compared with control eyes. We found an inverse correlation between SD-OCT parameters and MSSS ( p = 0.003) and between vessel density parameters and EDSS ( p = 0.007). CONCLUSION: We report a vessel density reduction in retina of MSpatients. We highlight the clinical correlation between vessel density and EDSS, suggesting that angio-OCT could be a good marker of disease and of disability in MS.
Authors: Hong Jiang; Giovana Rosa Gameiro; Yi Liu; Ying Lin; Jeffrey Hernandez; Yuqing Deng; Giovanni Gregori; Silvia Delgado; Jianhua Wang Journal: Am J Ophthalmol Date: 2020-01-08 Impact factor: 5.258
Authors: Olwen C Murphy; Ohemaa Kwakyi; Mustafa Iftikhar; Sidra Zafar; Jeffrey Lambe; Nicole Pellegrini; Elias S Sotirchos; Natalia Gonzalez-Caldito; Esther Ogbuokiri; Angeliki Filippatou; Hunter Risher; Norah Cowley; Sydney Feldman; Nicholas Fioravante; Elliot M Frohman; Teresa C Frohman; Laura J Balcer; Jerry L Prince; Roomasa Channa; Peter A Calabresi; Shiv Saidha Journal: Mult Scler Date: 2019-05-16 Impact factor: 6.312
Authors: Marta Para-Prieto; Raul Martin; Sara Crespo; Laura Mena-Garcia; Andres Valisena; Lisandro Cordero; Gloria Gonzalez Fernandez; Juan F Arenillas; Nieves Tellez; Jose Carlos Pastor Journal: Clin Ophthalmol Date: 2021-05-14