Yunhua Tang1,2,3, Ming Han1,2,3, Maogen Chen1,2,3, Xiaoping Wang1,2,3, Fei Ji1,2,3, Qiang Zhao1,2,3, Zhiheng Zhang1,2,3, Weiqiang Ju1,2,3, Dongping Wang1,2,3, Zhiyong Guo4,5,6, Xiaoshun He7,8,9. 1. Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou, 510080, China. 2. Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China. 3. Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China. 4. Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou, 510080, China. gdtrc@163.com. 5. Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China. gdtrc@163.com. 6. Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China. gdtrc@163.com. 7. Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou, 510080, China. rockyucsf1981@126.com. 8. Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China. rockyucsf1981@126.com. 9. Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China. rockyucsf1981@126.com.
Abstract
BACKGROUND: Transplantation centers have given much attention to donor availability. However, no reliable quantitative methods have been employed to accurately assess graft quality before transplantation. Here, we report that the indocyanine green (ICG) clearance test is a valuable index for liver grafts. METHODS: We performed the ICG clearance test on 90 brain-dead donors within 6 h before organ procurement between March 2015 and November 2016. We also analyzed the relationship between graft liver function and early graft survival after liver transplantation (LT). RESULTS: Our results suggest that the ICG retention rate at 15 min (ICGR15) of donors before procurement was independently associated with 3-month graft survival after LT. The best donor ICGR15 cutoff value was 11.0%/min, and we observed a significant increase in 3-month graft failure among patients with a donor ICGR15 above this value. On the other hand, a donor ICGR15 value of ≤ 11.0%/min could be used as an early assessment index of graft quality because it provides additional information to the transplant surgeon or organ procurement organization members who must maintain or improve organ function to adapt the LT. CONCLUSION: An ICG clearance test before liver procurement might be an effective quantitative method to predict graft availability and improve early graft prognosis after LT.
BACKGROUND: Transplantation centers have given much attention to donor availability. However, no reliable quantitative methods have been employed to accurately assess graft quality before transplantation. Here, we report that the indocyanine green (ICG) clearance test is a valuable index for liver grafts. METHODS: We performed the ICG clearance test on 90 brain-dead donors within 6 h before organ procurement between March 2015 and November 2016. We also analyzed the relationship between graft liver function and early graft survival after liver transplantation (LT). RESULTS: Our results suggest that the ICG retention rate at 15 min (ICGR15) of donors before procurement was independently associated with 3-month graft survival after LT. The best donor ICGR15 cutoff value was 11.0%/min, and we observed a significant increase in 3-month graft failure among patients with a donor ICGR15 above this value. On the other hand, a donor ICGR15 value of ≤ 11.0%/min could be used as an early assessment index of graft quality because it provides additional information to the transplant surgeon or organ procurement organization members who must maintain or improve organ function to adapt the LT. CONCLUSION: An ICG clearance test before liver procurement might be an effective quantitative method to predict graft availability and improve early graft prognosis after LT.
Entities:
Keywords:
Graft quality; Indocyanine green clearance test; Liver transplantation
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