Literature DB >> 28930290

Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations.

Richard Parker1,2, Seung-Jin Kim2, Bin Gao2.   

Abstract

Adipose tissue represents a large volume of biologically active tissue that exerts substantial systemic effects in health and disease. Alcohol consumption can profoundly disturb the normal functions of adipose tissue by inducing adipocyte death and altering secretion of adipokines, pro-inflammatory mediators and free fatty acids from adipose tissue, which have important direct and indirect effects on the pathogenesis of alcoholic liver disease (ALD). Cessation of alcohol intake quickly reverses inflammatory changes in adipose tissue, and pharmacological treatment that normalizes adipose tissue function improves experimental ALD. Obesity exacerbates liver injury induced by chronic or binge alcohol consumption, and obesity and alcohol can synergize to increase risk of ALD and progression. Physicians who care for individuals with ALD should be aware of the effects of adipose tissue dysfunction on liver function, and consider strategies to manage obesity and insulin resistance. This Review examines the effect of alcohol on adiposity and adipose tissue and the relationship between alcohol, adipose tissue and the liver.

Entities:  

Mesh：

Year:  2017        PMID： 28930290     DOI： 10.1038/nrgastro.2017.116

Source DB:  PubMed          Journal:  Nat Rev Gastroenterol Hepatol        ISSN： 1759-5045            Impact factor:   46.802


  205 in total

1.  Increased circulating leptin levels in chronic alcoholism.

Authors:  J M Nicolás; J Fernández-Solà; F Fatjó; R Casamitjana; R Bataller; E Sacanella; E Tobías; E Badía; R Estruch
Journal:  Alcohol Clin Exp Res       Date:  2001-01       Impact factor: 3.455

2.  Chronic ethanol feeding suppresses beta-adrenergic receptor-stimulated lipolysis in adipocytes isolated from epididymal fat.

Authors:  Li Kang; Laura E Nagy
Journal:  Endocrinology       Date:  2006-06-22       Impact factor: 4.736

3.  Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008.

Authors:  Zobair M Younossi; Maria Stepanova; Mariam Afendy; Yun Fang; Youssef Younossi; Hesham Mir; Manirath Srishord
Journal:  Clin Gastroenterol Hepatol       Date:  2011-03-25       Impact factor: 11.382

Review 4.  Alcoholic liver disease: pathogenesis and new therapeutic targets.

Authors:  Bin Gao; Ramon Bataller
Journal:  Gastroenterology       Date:  2011-09-12       Impact factor: 22.682

5.  Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects.

Authors:  Karine Clément; Nathalie Viguerie; Christine Poitou; Claire Carette; Véronique Pelloux; Cyrile A Curat; Audrey Sicard; Sophie Rome; Arriel Benis; Jean-Daniel Zucker; Hubert Vidal; Martine Laville; Gregory S Barsh; Arnaud Basdevant; Vladimir Stich; Raffaella Cancello; Dominique Langin
Journal:  FASEB J       Date:  2004-11       Impact factor: 5.191

6.  Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease.

Authors:  Zhenyuan Song; Zhanxiang Zhou; Ion Deaciuc; Theresa Chen; Craig J McClain
Journal:  Hepatology       Date:  2008-03       Impact factor: 17.425

7.  Alcohol consumption is associated with progression of hepatic fibrosis in non-alcoholic fatty liver disease.

Authors:  Mattias Ekstedt; Lennart E Franzén; Marika Holmqvist; Preben Bendtsen; Ulrik L Mathiesen; Göran Bodemar; Stergios Kechagias
Journal:  Scand J Gastroenterol       Date:  2009       Impact factor: 2.423

8.  Gender-dependent alterations in serum leptin in alcoholic cirrhosis.

Authors:  A J McCullough; E Bugianesi; G Marchesini; S C Kalhan
Journal:  Gastroenterology       Date:  1998-10       Impact factor: 22.682

9.  Association of lifestyle factors with abdominal subcutaneous and visceral adiposity: the Framingham Heart Study.

Authors:  Esther A Molenaar; Joseph M Massaro; Paul F Jacques; Karla M Pou; R Curtis Ellison; Udo Hoffmann; Karol Pencina; Steven D Shadwick; Ramachandran S Vasan; Christopher J O'Donnell; Caroline S Fox
Journal:  Diabetes Care       Date:  2008-12-15       Impact factor: 19.112

10.  Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis.

Authors:  Fatemeh Momen-Heravi; Banishree Saha; Karen Kodys; Donna Catalano; Abhishek Satishchandran; Gyongyi Szabo
Journal:  J Transl Med       Date:  2015-08-12       Impact factor: 5.531
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  45 in total

1.  How does your fat affect your liver when you drink?

Authors:  Seonghwan Hwang; Bin Gao
Journal:  J Clin Invest       Date:  2019-04-29       Impact factor: 14.808

2.  The Role of Energy Intake on Fitness-Adjusted Racial/Ethnic Differences in Central Adiposity Using Quantile Regression.

Authors:  Samantha M McDonald; Andrew Ortaglia; Christina Supino; Matteo Bottai
Journal:  J Racial Ethn Health Disparities       Date:  2019-01-17

3.  Epidemiological Realities of Alcoholic Liver Disease: Global Burden, Research Trends, and Therapeutic Promise.

Authors:  Jia Xiao; Fei Wang; Nai-Kei Wong; Yi Lv; Yingxia Liu; Jiajun Zhong; Shuaiyin Chen; Wei Li; Kazuo Koike; Xiaowei Liu; Hua Wang
Journal:  Gene Expr       Date:  2020-07-20

Review 4.  Alcoholic liver disease.

Authors:  Helmut K Seitz; Ramon Bataller; Helena Cortez-Pinto; Bin Gao; Antoni Gual; Carolin Lackner; Philippe Mathurin; Sebastian Mueller; Gyongyi Szabo; Hidekazu Tsukamoto
Journal:  Nat Rev Dis Primers       Date:  2018-08-16       Impact factor: 52.329

5.  Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation.

Authors:  Greta Trogen; Joshua Bacon; Ying Li; Gary L Wright; Ashley Degroat; Kendra L Hagood; Zachary Warren; Allan Forsman; Aruna Kilaru; W Andrew Clark; Jonathan M Peterson
Journal:  Am J Physiol Endocrinol Metab       Date:  2018-05-15       Impact factor: 4.310

6.  A Hepatocyte-Mimicking Antidote for Alcohol Intoxication.

Authors:  Duo Xu; Hui Han; Yuxin He; Harrison Lee; Di Wu; Fang Liu; Xiangsheng Liu; Yang Liu; Yunfeng Lu; Cheng Ji
Journal:  Adv Mater       Date:  2018-04-11       Impact factor: 30.849

Review 7.  Interleukin-22 in alcoholic hepatitis and beyond.

Authors:  Xiaogang Xiang; Seonghwan Hwang; Dechun Feng; Vijay H Shah; Bin Gao
Journal:  Hepatol Int       Date:  2020-09-05       Impact factor: 6.047

8.  KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation.

Authors:  Isabel Legaz; Jose Miguel Bolarín; Elena Navarro; Jose Antonio Campillo; Rosa Moya; María Dolores Pérez-Cárceles; Aurelio Luna; Eduardo Osuna; Manuel Miras; Manuel Muro; Alfredo Minguela; Rocio Alvarez López
Journal:  Arch Med Sci       Date:  2019-04-09       Impact factor: 3.318

9.  Adipocyte Death Preferentially Induces Liver Injury and Inflammation Through the Activation of Chemokine (C-C Motif) Receptor 2-Positive Macrophages and Lipolysis.

Authors:  Seung-Jin Kim; Dechun Feng; Adrien Guillot; Shen Dai; Fengming Liu; Seonghwan Hwang; Richard Parker; Wonhyo Seo; Yong He; Grzegorz Godlewski; Won-Il Jeong; Yuhong Lin; Xuebin Qin; George Kunos; Bin Gao
Journal:  Hepatology       Date:  2019-03-18       Impact factor: 17.425

10.  Ghrelin regulates adipose tissue metabolism: Role in hepatic steatosis.

Authors:  Karuna Rasineni; Jacy L Kubik; Kurt L Knight; Lukas Hall; Carol A Casey; Kusum K Kharbanda
Journal:  Chem Biol Interact       Date:  2020-03-11       Impact factor: 5.192
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