| Literature DB >> 29638019 |
Duo Xu1, Hui Han2, Yuxin He2, Harrison Lee2, Di Wu1, Fang Liu1, Xiangsheng Liu3, Yang Liu4, Yunfeng Lu1, Cheng Ji2.
Abstract
Alcohol intoxication causes serious diseases, whereas current treatments are mostly supportive and unable to remove alcohol efficiently. Upon alcohol consumption, alcohol is sequentially oxidized to acetaldehyde and acetate by the endogenous alcohol dehydrogenase and aldehyde dehydrogenase, respectively. Inspired by the metabolism of alcohol, a hepatocyte-mimicking antidote for alcohol intoxication through the codelivery of the nanocapsules of alcohol oxidase (AOx), catalase (CAT), and aldehyde dehydrogenase (ALDH) to the liver, where AOx and CAT catalyze the oxidation of alcohol to acetaldehyde, while ALDH catalyzes the oxidation of acetaldehyde to acetate. Administered to alcohol-intoxicated mice, the antidote rapidly accumulates in the liver and enables a significant reduction of the blood alcohol concentration. Moreover, blood acetaldehyde concentration is maintained at an extremely low level, significantly contributing to liver protection. Such an antidote, which can eliminate alcohol and acetaldehyde simultaneously, holds great promise for the treatment of alcohol intoxication and poisoning and can provide therapeutic benefits.Entities:
Keywords: alcohol detoxification; biomimetic antidotes; enzyme nanocapsules; nanomedicine
Year: 2018 PMID： 29638019 PMCID： PMC6386471 DOI： 10.1002/adma.201707443
Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849