Elodie Pongan1,2,3, Barbara Tillmann4, Yohana Leveque4, Béatrice Trombert5, Jean Claude Getenet1, Nicolas Auguste6, Virginie Dauphinot2,3, Hanane El Haouari1, Malou Navez1, Jean-Michel Dorey7, Pierre Krolak-Salmon2,3, Bernard Laurent1,8, Isabelle Rouch1,2,3. 1. Memory Clinical and Research Center of Saint Etienne (CMRR) Neurology Unit, University Hospital of Saint Etienne, Saint Etienne, France. 2. Memory Clinical and Research Center of Lyon (CMRR), Hospital of Charpennes, University Hospital of Lyon, France. 3. Institute of Aging I-Vie, University Hospital of Lyon, France. 4. INSERM, U1028; CNRS, UMR5292; Psychoacoustic and Auditory Cognition team, Lyon Neuroscience Research Center, Lyon, France. 5. Public Health and Medical Information Unit, University Hospital of Saint-Etienne, Saint Etienne, France. 6. Memory Clinical and Research Center of Saint Etienne (CMRR) Geriatrics Unit, University Hospital of Saint Etienne, Saint Etienne, France. 7. Department of Psychiatry, Hospital Le Vinatier, Bron, France. 8. INSERM, U1028; CNRS, UMR5292; Neuropain team, Lyon Neuroscience Research Center, Lyon, France.
Abstract
BACKGROUND: Among non-pharmacological therapies, musical intervention is often used for patients with Alzheimer's disease (AD) and patients presenting chronic pain. However, their efficacy is still under debate. OBJECTIVE: Our aim was to determine the efficacy of choral singing versus painting sessions on chronic pain, mood, quality of life, and cognition in AD patients. METHODS: In this multicenter randomized controlled trial, 59 mild AD patients were randomized to a 12-week singing (SG; n = 31) or painting group (PG; n = 28). Chronic pain, anxiety, depression, and quality of life were assessed before, after, and 1 month after the sessions. Cognitive abilities were assessed before and after interventions. The evolution of these different measures was assessed with mixed linear models. The primary data analysis was by intention-to-treat, and completed by a 'per protocol' approach. RESULTS: Both singing and painting interventions led to significant pain reduction (Time effect: F = 4.71; p = 0.01), reduced anxiety (Time effect: F = 10.74; p < 0.0001), improved Quality of Life (Time effect: F = 6.79; p = 0.002), improved digit span (F = 12.93; p = 0.001), and inhibitory processes (Time effect: F = 4.93; p = 0.03). Depression was reduced over time in PG only (Time x Group effect: F = 4.53; p = 0.01). Verbal Memory performance remained stable over time in SG, but decreased in PG (Time x group effect: F = 9.29; p = 0.004). CONCLUSION: Findings suggest that singing and painting interventions may reduce pain and improve mood, quality of life, and cognition in patients with mild AD, with differential effects of painting for depression and singing for memory performance.
RCT Entities:
BACKGROUND: Among non-pharmacological therapies, musical intervention is often used for patients with Alzheimer's disease (AD) and patients presenting chronic pain. However, their efficacy is still under debate. OBJECTIVE: Our aim was to determine the efficacy of choral singing versus painting sessions on chronic pain, mood, quality of life, and cognition in ADpatients. METHODS: In this multicenter randomized controlled trial, 59 mild ADpatients were randomized to a 12-week singing (SG; n = 31) or painting group (PG; n = 28). Chronic pain, anxiety, depression, and quality of life were assessed before, after, and 1 month after the sessions. Cognitive abilities were assessed before and after interventions. The evolution of these different measures was assessed with mixed linear models. The primary data analysis was by intention-to-treat, and completed by a 'per protocol' approach. RESULTS: Both singing and painting interventions led to significant pain reduction (Time effect: F = 4.71; p = 0.01), reduced anxiety (Time effect: F = 10.74; p < 0.0001), improved Quality of Life (Time effect: F = 6.79; p = 0.002), improved digit span (F = 12.93; p = 0.001), and inhibitory processes (Time effect: F = 4.93; p = 0.03). Depression was reduced over time in PG only (Time x Group effect: F = 4.53; p = 0.01). Verbal Memory performance remained stable over time in SG, but decreased in PG (Time x group effect: F = 9.29; p = 0.004). CONCLUSION: Findings suggest that singing and painting interventions may reduce pain and improve mood, quality of life, and cognition in patients with mild AD, with differential effects of painting for depression and singing for memory performance.
Authors: Jennie L Dorris; Stephen Neely; Lauren Terhorst; Helena M VonVille; Juleen Rodakowski Journal: J Am Geriatr Soc Date: 2021-05-18 Impact factor: 7.538
Authors: Nathan M D'Cunha; Andrew J McKune; Stephen Isbel; Jane Kellett; Ekavi N Georgousopoulou; Nenad Naumovski Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472