| Literature DB >> 28919308 |
Xiaowei Song1, Zhenyu Zeng2, Huanhuan Wei3, Zefeng Wang4.
Abstract
Alternative splicing is one of the most common mechanisms for gene regulation in humans, and plays a vital role to increase the complexity of functional proteins. In this article, we seek to provide a general review on the relationships between alternative splicing and tumorigenesis. We briefly introduce the basic rules for regulation of alternative splicing, and discuss recent advances on dynamic regulation of alternative splicing in cancers by highlighting the roles of a variety of RNA splicing factors in tumorigenesis. We further discuss several important questions regarding the splicing of long noncoding RNAs and back-splicing of circular RNAs in cancers. Finally, we discuss the current technologies that can be used to manipulate alternative splicing and serve as potential cancer treatment.Entities:
Keywords: Alternative splicing; Cancer; Engineered splicing factors; RNA-binding protein
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Year: 2017 PMID： 28919308 DOI： 10.1016/j.semcdb.2017.09.018
Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727