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Literature DB >> 28912134

ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.

Matthew J Schellenberg¹, Jenna Ariel Lieberman², Andrés Herrero-Ruiz², Logan R Butler¹, Jason G Williams³, Ana M Muñoz-Cabello², Geoffrey A Mueller¹, Robert E London¹, Felipe Cortés-Ledesma⁴, R Scott Williams⁵.

Abstract

Topoisomerase 2 (TOP2) DNA transactions proceed via formation of the TOP2 cleavage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is vulnerable to trapping by potent anticancer TOP2 drugs. How genotoxic TOP2 DNA-protein cross-links are resolved is unclear. We found that the SUMO (small ubiquitin-related modifier) ligase ZATT (ZNF451) is a multifunctional DNA repair factor that controls cellular responses to TOP2 damage. ZATT binding to TOP2cc facilitates a proteasome-independent tyrosyl-DNA phosphodiesterase 2 (TDP2) hydrolase activity on stalled TOP2cc. The ZATT SUMO ligase activity further promotes TDP2 interactions with SUMOylated TOP2, regulating efficient TDP2 recruitment through a "split-SIM" SUMO2 engagement platform. These findings uncover a ZATT-TDP2-catalyzed and SUMO2-modulated pathway for direct resolution of TOP2cc.

Entities: CellLine Chemical Disease Gene Species

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Year: 2017 PMID： 28912134 PMCID： PMC5623066 DOI： 10.1126/science.aam6468

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

54 in total

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5. Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity.

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Journal: Science Date: 2015-01-09 Impact factor: 47.728

8. FoXS: a web server for rapid computation and fitting of SAXS profiles.

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9. Features and development of Coot.

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10. Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.

Authors: Matthew J Schellenberg; Lalith Perera; Christina N Strom; Crystal A Waters; Brinda Monian; C Denise Appel; Caroline K Vilas; Jason G Williams; Dale A Ramsden; R Scott Williams
Journal: Nucleic Acids Res Date: 2016-04-08 Impact factor: 16.971

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Journal: Environ Mol Mutagen Date: 2020-07-09 Impact factor: 3.216

Review 2. Replication-Coupled DNA Repair.

Authors: David Cortez
Journal: Mol Cell Date: 2019-06-06 Impact factor: 17.970

3. ZNF451 stabilizes TWIST2 through SUMOylation and promotes epithelial-mesenchymal transition.

Authors: Wang Zeng; Shuchen Gu; Yi Yu; Yili Feng; Mu Xiao; Xin-Hua Feng
Journal: Am J Cancer Res Date: 2021-03-01 Impact factor: 6.166

4. A Role for VCP/p97 in the Processing of Drug-Stabilized TOP2-DNA Covalent Complexes.

Authors: Rebecca L Swan; Ian G Cowell; Caroline A Austin
Journal: Mol Pharmacol Date: 2021-05-03 Impact factor: 4.436

5. Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.

Authors: Evgeny Kiselev; Azhar Ravji; Jayakanth Kankanala; Jiashu Xie; Zhengqiang Wang; Yves Pommier
Journal: DNA Repair (Amst) Date: 2019-11-06

6. A Genetic Map of the Response to DNA Damage in Human Cells.

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Journal: Cell Date: 2020-07-09 Impact factor: 41.582