Literature DB >> 2890160

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

R M Hudziak1, J Schlessinger, A Ullrich.   

Abstract

The HER2 gene encodes a cell-surface glycoprotein with extensive homology to the epidermal growth factor receptor. Recently it was found to be amplified in about 30% of primary human breast malignancies. In experiments designed to assess the role of the HER2 gene in oncogenesis, we found that overexpression of unaltered HER2 coding sequences in NIH 3T3 cells resulted in cellular transformation and tumorigenesis.

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Year:  1987        PMID： 2890160      PMCID： PMC299249          DOI： 10.1073/pnas.84.20.7159

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  27 in total

1.  Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

Authors:  C I Bargmann; M C Hung; R A Weinberg
Journal:  Cell       Date:  1986-06-06       Impact factor: 41.582

2.  A new dominant hybrid selective marker for higher eukaryotic cells.

Authors:  F Colbère-Garapin; F Horodniceanu; P Kourilsky; A C Garapin
Journal:  J Mol Biol       Date:  1981-07-25       Impact factor: 5.469

3.  Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary dna gene.

Authors:  R J Kaufman; P A Sharp
Journal:  J Mol Biol       Date:  1982-08-25       Impact factor: 5.469

4.  Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

Authors:  F W Alt; R E Kellems; J R Bertino; R T Schimke
Journal:  J Biol Chem       Date:  1978-03-10       Impact factor: 5.157

5.  Activation of the transforming potential of a normal cell sequence: a molecular model for oncogenesis.

Authors:  D G Blair; M Oskarsson; T G Wood; W L McClements; P J Fischinger; G G Vande Woude
Journal:  Science       Date:  1981-05-22       Impact factor: 47.728

6.  Mapping temperature-sensitive and host-range mutations of adenovirus type 5 by marker rescue.

Authors:  E Frost; J Williams
Journal:  Virology       Date:  1978-11       Impact factor: 3.616

7.  Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin.

Authors:  T A Libermann; H R Nusbaum; N Razon; R Kris; I Lax; H Soreq; N Whittle; M D Waterfield; A Ullrich; J Schlessinger
Journal:  Nature       Date:  1985 Jan 10-18       Impact factor: 49.962

8.  Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.

Authors:  J Downward; Y Yarden; E Mayes; G Scrace; N Totty; P Stockwell; A Ullrich; J Schlessinger; M D Waterfield
Journal:  Nature       Date:  1984 Feb 9-15       Impact factor: 49.962

9.  Analysis of processing and polyadenylation signals of the hepatitis B virus surface antigen gene by using simian virus 40-hepatitis B virus chimeric plasmids.

Authors:  C C Simonsen; A D Levinson
Journal:  Mol Cell Biol       Date:  1983-12       Impact factor: 4.272

10.  Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

Authors:  M H Kraus; N C Popescu; S C Amsbaugh; C R King
Journal:  EMBO J       Date:  1987-03       Impact factor: 11.598
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  148 in total

Review 1.  Mediterranean diet, olive oil and cancer.

Authors:  Ramón Colomer; Javier A Menéndez
Journal:  Clin Transl Oncol       Date:  2006-01       Impact factor: 3.405

Review 2.  Early detection of chemotherapy-related left ventricular dysfunction.

Authors:  Jeanne M DeCara
Journal:  Curr Cardiol Rep       Date:  2012-06       Impact factor: 2.931

Review 3.  Application of molecular cytogenetic techniques to the evaluation of renal parenchymal tumors.

Authors:  G Kovacs
Journal:  J Cancer Res Clin Oncol       Date:  1990       Impact factor: 4.553

Review 4.  The ERBB network: at last, cancer therapy meets systems biology.

Authors:  Yosef Yarden; Gur Pines
Journal:  Nat Rev Cancer       Date:  2012-07-12       Impact factor: 60.716

5.  An adenoviral vaccine encoding full-length inactivated human Her2 exhibits potent immunogenicty and enhanced therapeutic efficacy without oncogenicity.

Authors:  Zachary C Hartman; Junping Wei; Takuya Osada; Oliver Glass; Gangjun Lei; Xiao-Yi Yang; Sharon Peplinski; Dong-Wan Kim; Wenle Xia; Neil Spector; Jeffrey Marks; William Barry; Amy Hobeika; Gayathri Devi; Andrea Amalfitano; Michael A Morse; H Kim Lyerly; Timothy M Clay
Journal:  Clin Cancer Res       Date:  2010-02-23       Impact factor: 12.531

Review 6.  The ErbB receptors as targets for breast cancer therapy.

Authors:  J Albanell; J Baselga
Journal:  J Mammary Gland Biol Neoplasia       Date:  1999-10       Impact factor: 2.673

7.  Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation.

Authors:  Nadia Godin-Heymann; Ianthe Bryant; Miguel N Rivera; Lindsey Ulkus; Daphne W Bell; David J Riese; Jeffrey Settleman; Daniel A Haber
Journal:  Cancer Res       Date:  2007-08-01       Impact factor: 12.701

Review 8.  The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis.

Authors:  M M Moasser
Journal:  Oncogene       Date:  2007-04-30       Impact factor: 9.867

9.  MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivity in vivo.

Authors:  Y Liu; D el-Ashry; D Chen; I Y Ding; F G Kern
Journal:  Breast Cancer Res Treat       Date:  1995-05       Impact factor: 4.872

10.  Frequent expression of genes for receptor tyrosine kinases and their ligands in human pancreatic cancer cells.

Authors:  T Oikawa; J Hitomi; A Kono; E Kaneko; K Yamaguchi
Journal:  Int J Pancreatol       Date:  1995-08
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