| Literature DB >> 7233190 |
D G Blair, M Oskarsson, T G Wood, W L McClements, P J Fischinger, G G Vande Woude.
Abstract
The molecularly cloned, long terminal repeat (LTR) of the Moloney sarcoma virus (M-MSV) provirus has been covalently linked to c-mos, the cellular homolog of the M-MSV-specific sequence, v-mos. These newly constructed clones lack any M-MSV-derived sequences other than the LTR, but in DNA transfection assays they transform cells as efficiently as cloned subgenomic M-MSV fragments containing both v-mos and LTR. Cells transformed by LTR:c-mos hybrid molecules contain additional copies of mos DNA, and several size classes of polyadenylated RNA's with sequence homology to mos. The activation of the transforming potential of c-mos by the proviral LTR suggests a model whereby LTR-like elements could activate other normal cell sequences with oncogenic potential.Entities:
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Year: 1981 PMID： 7233190 DOI： 10.1126/science.7233190
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728