Literature DB >> 7594766

Frequent expression of genes for receptor tyrosine kinases and their ligands in human pancreatic cancer cells.

T Oikawa1, J Hitomi, A Kono, E Kaneko, K Yamaguchi.   

Abstract

Limited information is available concerning the involvement of growth factor receptors and their ligands in the pathogenesis of human pancreatic cancer. We analyzed 12 human pancreatic cancer cell lines by Northern blot analysis for the expression of 9 receptor tyrosine kinase (RTKs) and 6 growth factors. The effect of a monoclonal antibody (MAb) against transforming growth factor-alpha (TGF-alpha) on in vitro pancreatic cancer cell growth was also assessed, mRNA for EGF-R, c-erbB-2 and c-erbB-3 was expressed in 12 (100%), 12 (100%), and 7 (58%), respectively, of the cell lines examined. In addition, 8 (67%) cell lines expressed the c-met/receptor for hepatocyte growth factor. As for ligands, TGF-alpha mRNA was detected in 10 (83%) cell lines; MAb against TGF-alpha inhibited growth of the 2 cell lines examined. Furthermore, mRNA for amphiregulin (AR) was expressed in 10 (83%) cell lines. Coexpression of TGF-alpha, AR, and EGF-R was observed in 9 (75%) cell lines. These results support the concept that several specified types of RTKs and their ligands are closely involved in regulation of the growth of human pancreatic cancer cells.

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Year:  1995        PMID： 7594766     DOI： 10.1007/BF02825417

Source DB:  PubMed          Journal:  Int J Pancreatol        ISSN： 0169-4197


  62 in total

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Journal:  Cancer Res       Date:  1991-12-01       Impact factor: 12.701

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Journal:  J Clin Invest       Date:  1992-10       Impact factor: 14.808

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Journal:  Mol Cell Biol       Date:  1990-05       Impact factor: 4.272

10.  Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon.

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  8 in total

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2.  Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer.

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Authors:  Lidiya Orlichenko; Shaun G Weller; Hong Cao; Eugene W Krueger; Muyiwa Awoniyi; Galina Beznoussenko; Roberto Buccione; Mark A McNiven
Journal:  Mol Biol Cell       Date:  2009-07-29       Impact factor: 4.138

4.  The inhibitory effect of an EGF receptor-specific tyrosine kinase inhibitor on pancreatic cancer cell lines was more potent than inhibitory antibodies against the receptors for EGF and IGF I.

Authors:  M Kobari; B Kullenberg; A Björkman; S Matsuno; I Ihse; J Axelson
Journal:  Int J Pancreatol       Date:  1998-10

5.  Comparative phenotypic studies of duct epithelial cell lines derived from normal human pancreas and pancreatic carcinoma.

Authors:  N Liu; T Furukawa; M Kobari; M S Tsao
Journal:  Am J Pathol       Date:  1998-07       Impact factor: 4.307

6.  Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells.

Authors:  Andrew J Shirk; Rahul Kuver
Journal:  BMC Gastroenterol       Date:  2005-03-31       Impact factor: 3.067

7.  Enhancing sorafenib-mediated sensitization to gemcitabine in experimental pancreatic cancer through EMAP II.

Authors:  Niranjan Awasthi; Changhua Zhang; Stefan Hinz; Margaret A Schwarz; Roderich E Schwarz
Journal:  J Exp Clin Cancer Res       Date:  2013-03-06

8.  Inflammation to cancer: The molecular biology in the pancreas (Review).

Authors:  Sunbin Ling; Tingting Feng; Kaiqi Jia; Yu Tian; Yan Li
Journal:  Oncol Lett       Date:  2014-03-28       Impact factor: 2.967
  8 in total

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