Literature DB >> 6266567

Leukotriene B4: a mediator of vascular permeability.

M A Bray, F M Cunningham, A W Ford-Hutchinson, M J Smith.   

Abstract

1 Intradermal injection of leukotriene B4 (LTB4) or prostaglandin E2 (PGE2), 1 to 100 ng per skin site produced little or no change in plasma exudation in the rabbit, guinea-pig and rat. 2 Intradermal injection of LTB4 or PGE2 together with bradykinin (500 ng) resulted in a significant potentiation of the plasma exudation produced by bradykinin alone in the rabbit and guinea-pig. 4 LTB4 (1 to 10 ng) had no effect on blood flow in the rabbit skin, in contrast to PGE2 which was a potent vasodilator in this species. 5 It is concluded that LTB4 is a mediator of vascular permeability and that this effect can only be observed in the presence of a vasodilator such as PGE2.

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Year:  1981        PMID： 6266567      PMCID： PMC2071580          DOI： 10.1111/j.1476-5381.1981.tb11000.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  PGI2: a potential mediator of inflammation.

Authors:  A W Ford-Hutchinson; J R Walker; E M Davidson; M J Smith
Journal:  Prostaglandins       Date:  1978-08

2.  Prostaglandins as potentiators of increased vascular permeability in inflammation.

Authors:  T J Williams; J Morley
Journal:  Nature       Date:  1973-11-23       Impact factor: 49.962

3.  Slow-reacting substance of anaphylaxis: studies on purification and characterisation.

Authors:  H R Morris; G W Taylor; P J Piper; J R Tippins
Journal:  Agents Actions Suppl       Date:  1979

4.  Leukotriene A: stereochemistry and enzymatic conversion to leukotriene B.

Authors:  O Rådmark; C Malmsten; B Samuelsson; D A Clark; G Goto; A Marfat; E J Corey
Journal:  Biochem Biophys Res Commun       Date:  1980-02-12       Impact factor: 3.575

5.  Nomenclature for leukotrienes.

Authors:  B Samuelsson; S Hammarström
Journal:  Prostaglandins       Date:  1980-05

6.  Role of prostaglandin-mediated vasodilatation in inflammation.

Authors:  T J Williams; M J Peck
Journal:  Nature       Date:  1977-12-08       Impact factor: 49.962

7.  Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation.

Authors:  T J Williams
Journal:  Br J Pharmacol       Date:  1979-03       Impact factor: 8.739

8.  Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187.

Authors:  P Borgeat; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

9.  The regulation of human eosinophil function by endogenous mono-hydroxy-eicosatetraenoic acids (HETEs).

Authors:  E J Goetzl; P F Weller; F F Sun
Journal:  J Immunol       Date:  1980-02       Impact factor: 5.422

10.  Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds.

Authors:  P Borgeat; B Samuelsson
Journal:  J Biol Chem       Date:  1979-08-25       Impact factor: 5.157
  10 in total
  46 in total

1.  Leukotriene B4 and prostaglandin E2 mediate the inflammatory response of rabbit skin to intradermal arachidonic acid.

Authors:  D M Aked; S J Foster
Journal:  Br J Pharmacol       Date:  1987-11       Impact factor: 8.739

2.  The inflammatory response of rabbit skin to topical arachidonic acid and its pharmacological modulation.

Authors:  D Aked; S J Foster; A Howarth; M E McCormick; H C Potts
Journal:  Br J Pharmacol       Date:  1986-10       Impact factor: 8.739

3.  Characterization of a polyacrylamide gel-induced granuloma in mice: involvement of arachidonate metabolites.

Authors:  M Errasfa; F Russo-Marie
Journal:  Agents Actions       Date:  1988-06

Review 4.  Leukotrienes in inflammation.

Authors:  M A Bray
Journal:  Agents Actions       Date:  1986-10

5.  Effect of thiol-activated toxins (streptolysin O, alveolysin, and theta toxin) on the generation of leukotrienes and leukotriene-inducing and -metabolizing enzymes from human polymorphonuclear granulocytes.

Authors:  K D Bremm; W König; P Pfeiffer; I Rauschen; K Theobald; M Thelestam; J E Alouf
Journal:  Infect Immun       Date:  1985-12       Impact factor: 3.441

6.  Vasoactive intestinal polypeptide is more potent than prostaglandin E2 as a vasodilator and oedema potentiator in rabbit skin.

Authors:  T J Williams
Journal:  Br J Pharmacol       Date:  1982-11       Impact factor: 8.739

7.  Generation of leukotrienes from human granulocytes by alveolysin from Bacillus alvei.

Authors:  K D Bremm; H J Brom; J E Alouf; W König; B Spur; A Crea; W Peters
Journal:  Infect Immun       Date:  1984-04       Impact factor: 3.441

8.  The in vivo effect of leukotriene B4 on polymorphonuclear leukocytes and the microcirculation. Comparison with activated complement (C5a des Arg) and enhancement by prostaglandin E2.

Authors:  H Z Movat; C Rettl; C E Burrowes; M G Johnston
Journal:  Am J Pathol       Date:  1984-05       Impact factor: 4.307

9.  Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration.

Authors:  M Rampart; T J Williams
Journal:  Am J Pathol       Date:  1986-07       Impact factor: 4.307

Review 10.  Leukotrienes, allergy and inflammation.

Authors:  F P Nijkamp; J M Sitsen
Journal:  Pharm Weekbl Sci       Date:  1982-12-17
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