Literature DB >> 28886363

CRISPR: Established Editor of Human Embryos?

Xiao-Jiang Li1, Zhuchi Tu2, Weili Yang2, Shihua Li3.   

Abstract

Off-target effects and mosaicism are major concerns for applying CRISPR-Cas9 to correct genetic mutations. A recent article in Nature by Ma et al. (2017) uses an elegant CRISPR-Cas9 approach that repairs a genetic mutation in human embryos with negligible mosaicism and no off-target effects, bringing this editing tool closer to clinical application.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28886363      PMCID： PMC5819596          DOI： 10.1016/j.stem.2017.08.007

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  10 in total

Review 1.  Remodelling the paternal chromatin at fertilization in mammals.

Authors:  David W McLay; Hugh J Clarke
Journal:  Reproduction       Date:  2003-05       Impact factor: 3.906

2.  Chromosome instability is common in human cleavage-stage embryos.

Authors:  Evelyne Vanneste; Thierry Voet; Cédric Le Caignec; Michèle Ampe; Peter Konings; Cindy Melotte; Sophie Debrock; Mustapha Amyere; Miikka Vikkula; Frans Schuit; Jean-Pierre Fryns; Geert Verbeke; Thomas D'Hooghe; Yves Moreau; Joris R Vermeesch
Journal:  Nat Med       Date:  2009-04-26       Impact factor: 53.440

3.  Correction of a pathogenic gene mutation in human embryos.

Authors:  Hong Ma; Nuria Marti-Gutierrez; Sang-Wook Park; Jun Wu; Yeonmi Lee; Keiichiro Suzuki; Amy Koski; Dongmei Ji; Tomonari Hayama; Riffat Ahmed; Hayley Darby; Crystal Van Dyken; Ying Li; Eunju Kang; A-Reum Park; Daesik Kim; Sang-Tae Kim; Jianhui Gong; Ying Gu; Xun Xu; David Battaglia; Sacha A Krieg; David M Lee; Diana H Wu; Don P Wolf; Stephen B Heitner; Juan Carlos Izpisua Belmonte; Paula Amato; Jin-Soo Kim; Sanjiv Kaul; Shoukhrat Mitalipov
Journal:  Nature       Date:  2017-08-02       Impact factor: 49.962

4.  CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein.

Authors:  Lichun Tang; Yanting Zeng; Hongzi Du; Mengmeng Gong; Jin Peng; Buxi Zhang; Ming Lei; Fang Zhao; Weihua Wang; Xiaowei Li; Jianqiao Liu
Journal:  Mol Genet Genomics       Date:  2017-03-01       Impact factor: 3.291

5.  Mitosis inhibits DNA double-strand break repair to guard against telomere fusions.

Authors:  Alexandre Orthwein; Amélie Fradet-Turcotte; Sylvie M Noordermeer; Marella D Canny; Catherine M Brun; Jonathan Strecker; Cristina Escribano-Diaz; Daniel Durocher
Journal:  Science       Date:  2014-03-20       Impact factor: 47.728

6.  Implications of human genetic variation in CRISPR-based therapeutic genome editing.

Authors:  David A Scott; Feng Zhang
Journal:  Nat Med       Date:  2017-07-31       Impact factor: 53.440

7.  Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9.

Authors:  Yongchang Chen; Yinghui Zheng; Yu Kang; Weili Yang; Yuyu Niu; Xiangyu Guo; Zhuchi Tu; Chenyang Si; Hong Wang; Ruxiao Xing; Xiuqiong Pu; Shang-Hsun Yang; Shihua Li; Weizhi Ji; Xiao-Jiang Li
Journal:  Hum Mol Genet       Date:  2015-04-09       Impact factor: 6.150

8.  Unexpected mutations after CRISPR-Cas9 editing in vivo.

Authors:  Kellie A Schaefer; Wen-Hsuan Wu; Diana F Colgan; Stephen H Tsang; Alexander G Bassuk; Vinit B Mahajan
Journal:  Nat Methods       Date:  2017-05-30       Impact factor: 28.547

9.  CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes.

Authors:  Puping Liang; Yanwen Xu; Xiya Zhang; Chenhui Ding; Rui Huang; Zhen Zhang; Jie Lv; Xiaowei Xie; Yuxi Chen; Yujing Li; Ying Sun; Yaofu Bai; Zhou Songyang; Wenbin Ma; Canquan Zhou; Junjiu Huang
Journal:  Protein Cell       Date:  2015-04-18       Impact factor: 14.870

10.  Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos.

Authors:  Zhuchi Tu; Weili Yang; Sen Yan; An Yin; Jinquan Gao; Xudong Liu; Yinghui Zheng; Jiezhao Zheng; Zhujun Li; Su Yang; Shihua Li; Xiangyu Guo; Xiao-Jiang Li
Journal:  Sci Rep       Date:  2017-02-03       Impact factor: 4.379
  10 in total

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