Literature DB >> 28882413

cGAS Conducts Micronuclei DNA Surveillance.

Carina C de Oliveira Mann1, Philip J Kranzusch2.   

Abstract

DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the immune sensor cyclic GMP-AMP synthase (cGAS) in micronuclei leads to a cell-cycle-dependent proinflammatory response following DNA damage.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  DNA damage; STING; cGAS; innate immune signaling; micronuclei

Mesh：

Substances：

Year:  2017        PMID： 28882413     DOI： 10.1016/j.tcb.2017.08.007

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  23 in total

Review 1.  Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells.

Authors:  Teressa Paulsen; Pankaj Kumar; M Murat Koseoglu; Anindya Dutta
Journal:  Trends Genet       Date:  2018-01-09       Impact factor: 11.639

Review 2.  Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy.

Authors:  Elena García-Martínez; Melody Smith; Aitziber Buqué; Fernando Aranda; Francisco Ayala de la Peña; Alejandra Ivars; Manuel Sanchez Cánovas; Ma Angeles Vicente Conesa; Jitka Fucikova; Radek Spisek; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2018-02-15       Impact factor: 8.110

Review 3.  Control of innate immunity by the cGAS-STING pathway.

Authors:  Kenta Mosallanejad; Jonathan C Kagan
Journal:  Immunol Cell Biol       Date:  2022-05-25       Impact factor: 5.853

Review 4.  Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities.

Authors:  Vinod P Balachandran; Gregory L Beatty; Stephanie K Dougan
Journal:  Gastroenterology       Date:  2019-01-18       Impact factor: 22.682

Review 5.  Targeting innate sensing in the tumor microenvironment to improve immunotherapy.

Authors:  Zhida Liu; Chuanhui Han; Yang-Xin Fu
Journal:  Cell Mol Immunol       Date:  2019-12-16       Impact factor: 11.530

Review 6.  Aneuploidy as a promoter and suppressor of malignant growth.

Authors:  Anand Vasudevan; Klaske M Schukken; Erin L Sausville; Vishruth Girish; Oluwadamilare A Adebambo; Jason M Sheltzer
Journal:  Nat Rev Cancer       Date:  2021-01-11       Impact factor: 69.800

Review 7.  Radiation-Induced Chromosomal Aberrations and Immunotherapy: Micronuclei, Cytosolic DNA, and Interferon-Production Pathway.

Authors:  Marco Durante; Silvia C Formenti
Journal:  Front Oncol       Date:  2018-05-29       Impact factor: 6.244

8.  N-Acetyltransferase 10 Promotes Micronuclei Formation to Activate the Senescence-Associated Secretory Phenotype Machinery in Colorectal Cancer Cells.

Authors:  Yanan Cao; Mengfei Yao; Yaqian Wu; Ningning Ma; Haijing Liu; Bo Zhang
Journal:  Transl Oncol       Date:  2020-05-16       Impact factor: 4.243

9.  Trisomy 21-associated increases in chromosomal instability are unmasked by comparing isogenic trisomic/disomic leukocytes from people with mosaic Down syndrome.

Authors:  Kelly Rafferty; Kellie J Archer; Kristi Turner; Ruth Brown; Colleen Jackson-Cook
Journal:  PLoS One       Date:  2021-07-20       Impact factor: 3.240

10.  Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer.

Authors:  Sayeda Yasmin-Karim; Patrick T Bruck; Michele Moreau; Sijumon Kunjachan; Gui Zhen Chen; Rajiv Kumar; Stephanie Grabow; Stephanie K Dougan; Wilfred Ngwa
Journal:  Front Immunol       Date:  2018-09-07       Impact factor: 7.561
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