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Literature DB >> 2887586

Differential protooncogene expression characterizes histopathologically indistinguishable tumors of the peripheral nervous system.

C J Thiele, C McKeon, T J Triche, R A Ross, C P Reynolds, M A Israel.

Abstract

We have found highly predictable patterns of protooncogene expression in cell lines and tumor tissue of neuroblastoma (NB), a tumor of the peripheral nervous system (PNS). These patterns make it possible to recognize two different genetically definable subgroups among histopathologically indistinguishable tumors. Additionally, we have identified a difference in neurotransmitter biosynthetic enzyme activity in these two subgroups of NB. The patterns of protooncogene expression and neurotransmitter biosynthetic enzymes suggests that these tumors arise in different cells of the PNS.

Entities: Disease

Mesh：

Substances：
Neurotransmitter Agents

Year: 1987 PMID： 2887586 PMCID： PMC442306 DOI： 10.1172/JCI113137

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

53 in total

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