Literature DB >> 1357630

A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system.

R G Collum1, P E Fisher, M Datta, S Mellis, C Thiele, K Huebner, C M Croce, M A Israel, T Theil, T Moroy.   

Abstract

We report the isolation of a novel human POU domain encoding gene named RDC-1. The POU domain of the RDC-1 encoded protein is highly related to the POU domain potentially encoded by the rat brain-3 sequence and to that of the Drosophila I-POU protein; outside of the POU region, RDC-1 is unrelated to any previously characterized protein. The RDC-1 gene is expressed almost exclusively in normal tissues and transformed cells of neural origin. In the developing mouse and human fetus, RDC-1 is expressed in a spatially and temporally restricted pattern that suggests a critical role in the differentiation of neuronal tissues. In addition, RDC-1 is expressed in a unique subset of tumors of the peripheral nervous system including neuroepitheliomas and Ewing's sarcomas but not neuroblastomas. Based on its unique structural characteristics and expression pattern, we discuss potential functions for the RDC-1 protein.

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Year:  1992        PMID： 1357630      PMCID： PMC334251          DOI： 10.1093/nar/20.18.4919

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  25 in total

1.  A rearranged transforming gene, tre, is made up of human sequences derived from chromosome regions 5q, 17q and 18q.

Authors:  K Huebner; L A Cannizzaro; T Nakamura; J Hillova; R Mariage-Samson; F Hecht; M Hill; C M Croce
Journal:  Oncogene       Date:  1988-10       Impact factor: 9.867

2.  A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype.

Authors:  H A Ingraham; R P Chen; H J Mangalam; H P Elsholtz; S E Flynn; C R Lin; D M Simmons; L Swanson; M G Rosenfeld
Journal:  Cell       Date:  1988-11-04       Impact factor: 41.582

3.  The POU domain is a bipartite DNA-binding structure.

Authors:  R A Sturm; W Herr
Journal:  Nature       Date:  1988-12-08       Impact factor: 49.962

4.  Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region.

Authors:  A L Bothwell; M Paskind; M Reth; T Imanishi-Kari; K Rajewsky; D Baltimore
Journal:  Cell       Date:  1981-06       Impact factor: 41.582

5.  Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas.

Authors:  M Dürst; C M Croce; L Gissmann; E Schwarz; K Huebner
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

6.  Establishment and identification of small cell lung cancer cell lines having classic and variant features.

Authors:  D N Carney; A F Gazdar; G Bepler; J G Guccion; P J Marangos; T W Moody; M H Zweig; J D Minna
Journal:  Cancer Res       Date:  1985-06       Impact factor: 12.701

7.  The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.

Authors:  H A Ingraham; S E Flynn; J W Voss; V R Albert; M S Kapiloff; L Wilson; M G Rosenfeld
Journal:  Cell       Date:  1990-06-15       Impact factor: 41.582

8.  Differential protooncogene expression characterizes histopathologically indistinguishable tumors of the peripheral nervous system.

Authors:  C J Thiele; C McKeon; T J Triche; R A Ross; C P Reynolds; M A Israel
Journal:  J Clin Invest       Date:  1987-09       Impact factor: 14.808

9.  Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma.

Authors:  C McKeon; C J Thiele; R A Ross; M Kwan; T J Triche; J S Miser; M A Israel
Journal:  Cancer Res       Date:  1988-08-01       Impact factor: 12.701

10.  Transcription and DNA sequence of the BamHI L fragment of B95-8 Epstein-Barr virus.

Authors:  M Biggin; P J Farrell; B G Barrell
Journal:  EMBO J       Date:  1984-05       Impact factor: 11.598
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  13 in total

1.  A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells.

Authors:  H Nakagoshi; M Hoshi; Y Nabeshima; F Matsuzaki
Journal:  Genes Dev       Date:  1998-09-01       Impact factor: 11.361

Review 2.  POU domain transcription factors in embryonic development.

Authors:  G J Veenstra; P C van der Vliet; O H Destrée
Journal:  Mol Biol Rep       Date:  1997-08       Impact factor: 2.316

3.  A novel Brn3-like POU transcription factor expressed in subsets of rat sensory and spinal cord neurons.

Authors:  N N Ninkina; G E Stevens; J N Wood; W D Richardson
Journal:  Nucleic Acids Res       Date:  1993-07-11       Impact factor: 16.971

4.  The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain.

Authors:  P J Morris; T Theil; C J Ring; K A Lillycrop; T Moroy; D S Latchman
Journal:  Mol Cell Biol       Date:  1994-10       Impact factor: 4.272

5.  The DNA target site for the Brn-3 POU family transcription factors can confer responsiveness to cyclic AMP and removal of serum in neuronal cells.

Authors:  V Budhram-Mahadeo; T Theil; P J Morris; K A Lillycrop; T Moroy; D S Latchman
Journal:  Nucleic Acids Res       Date:  1994-08-11       Impact factor: 16.971

Review 6.  Cell lineage and cell death: Caenorhabditis elegans and cancer research.

Authors:  Malia B Potts; Scott Cameron
Journal:  Nat Rev Cancer       Date:  2010-12-02       Impact factor: 60.716

7.  Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a.

Authors:  T Theil; S McLean-Hunter; M Zörnig; T Möröy
Journal:  Nucleic Acids Res       Date:  1993-12-25       Impact factor: 16.971

8.  Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.

Authors:  A K Bhargava; Z Li; S M Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

9.  The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain.

Authors:  C J Ring; D S Latchman
Journal:  Nucleic Acids Res       Date:  1993-06-25       Impact factor: 16.971

10.  Transcription factors interacting with herpes simplex virus alpha gene promoters in sensory neurons.

Authors:  M Hagmann; O Georgiev; W Schaffner; P Douville
Journal:  Nucleic Acids Res       Date:  1995-12-25       Impact factor: 16.971
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