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Literature DB >> 6245092

Characterization of polyoma viral DNA sequences in polyoma-induced hamster tumor cell lines.

M A Israel, D F Vanderryn, M L Meltzer, M A Martin.

Abstract

The polyoma (PY) viral DNA sequences present in a series of hamster tumor cell lines were evaluated using the blotting technique of Southern ((1975) J. Mol. Biol. 98, 503-517). Remarkably, no cell line contained an intact distal portion of the early gene region which encodes a portion of the large T antigen. All cell lines examined contained the PY DNA Bum I fragment which contains most of the genetic information encoding PY small and middle T antigens, as well as the origin of viral DNA replication. These results provide an explanation for our previous observation that PY virus-induced hamster tumors do not contain the large species of T antigen.

Entities: Disease

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Year: 1980 PMID： 6245092

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

32 in total

1. Mutation in the polyomavirus genome that activates the properties of large T associated with neoplastic transformation.

Authors: C Asselin; J Vass-Marengo; M Bastin
Journal: J Virol Date: 1986-01 Impact factor: 5.103

2. Properties of cells transformed by the middle T-antigen-coding region of polyomavirus.

Authors: C Priehs; K Friderici; L Winberry; M M Fluck
Journal: J Virol Date: 1986-01 Impact factor: 5.103

3. T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus.

Authors: Masahiro Shuda; Huichen Feng; Hyun Jin Kwun; Steven T Rosen; Ole Gjoerup; Patrick S Moore; Yuan Chang
Journal: Proc Natl Acad Sci U S A Date: 2008-09-23 Impact factor: 11.205

4. Cloning of endogenous murine leukemia virus-related sequences from chromosomal DNA of BALB/c and AKR/J mice: identification of an env progenitor of AKR-247 mink cell focus-forming proviral DNA.

Authors: A S Khan; W P Rowe; M A Martin
Journal: J Virol Date: 1982-11 Impact factor: 5.103

Characterization of polyoma viral DNA sequences in polyoma-induced hamster tumor cell lines.

1. Mutation in the polyomavirus genome that activates the properties of large T associated with neoplastic transformation.

2. Properties of cells transformed by the middle T-antigen-coding region of polyomavirus.

3. T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus.

4. Cloning of endogenous murine leukemia virus-related sequences from chromosomal DNA of BALB/c and AKR/J mice: identification of an env progenitor of AKR-247 mink cell focus-forming proviral DNA.

5. Characterization and partial nucleotide sequence of endogenous type C retrovirus segments in human chromosomal DNA.

6. A cloned polyoma DNA fragment representing the 5' half of the early gene region is oncogenic.

7. Identification of ecotropic proviral sequences in inbred mouse strains with a cloned subgenomic DNA fragment.

8. Characterization of proviruses cloned from mink cell focus-forming virus-infected cellular DNA.

9. Cloning and characterization of an envelope-specific probe from xenotropic murine leukemia proviral DNA.

10. Stability of polyoma DNA sequences and virus-coded proteins during tumor formation.