Almudena Sánchez-Villegas1,2, Aurora Pérez-Cornago3, Itziar Zazpe4,5, Susana Santiago5, Francisca Lahortiga6, Miguel Angel Martínez-González4,7,8. 1. Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, C/Dr. Pasteur s/n, Trasera Hospital Insular, CP 35016, Las Palmas de Gran Canaria, Spain. almudena.sanchez@ulpgc.es. 2. Ciber de Fisiopatología de la Obesidad y Nutrición (CIBER OBN), Instituto de Salud Carlos III, 28029, Madrid, Spain. almudena.sanchez@ulpgc.es. 3. Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. 4. Ciber de Fisiopatología de la Obesidad y Nutrición (CIBER OBN), Instituto de Salud Carlos III, 28029, Madrid, Spain. 5. Department of Nutrition and Food Sciences and Physiology, University of Navarra-IDISNA, 31008, Pamplona, Spain. 6. Department of Psychiatry and Medical Psychology, University Clinic of Navarra, 31008, Pamplona, Spain. 7. Department of Preventive Medicine and Public Health, University of Navarra-IDISNA, 31008, Navarra, Spain. 8. Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, 02115, USA.
Abstract
PURPOSE: The aim of the study was to prospectively assess the association between micronutrient intake adequacy and risk of depression. METHODS: This dynamic cohort study involves Spanish university graduates (SUN Project). Dietary intake was assessed at baseline and after 10 years of follow-up with a semi-quantitative food frequency questionnaire. Micronutrient intake adequacy for vitamins B1, B2, B3, B6, B12, C, A, D, E, folic acid, zinc, iodine, selenium, iron, calcium, potassium, phosphorus, magnesium and chrome was estimated. Inadequate intake for each nutrient was defined when the intake of the nutrient was below the estimated average requirements (EAR) if available or the adequate intake levels, if EARs were not available. We compared participants with inadequate intake for ≥4 nutrients vs. those with one nutrient. Participants were classified as having incident depression if they had no previous history of depression or antidepressants use at baseline, but they reported during follow-up a new clinical diagnosis of depression by a physician, use of antidepressant drugs, or both. Time-dependent multivariable Cox regression models were fitted. RESULTS: After a median follow-up of 8.5 years, 953 new cases of depression were observed among 13,983 participants. Participants with inadequate intake for ≥4 nutrients showed a significantly higher risk of depression [multivariable hazard ratio (HR) = 1.37; 95% confidence interval (CI) 1.01-1.85]. When the analyses were updated with repeated assessments of intakes, the association was attenuated and it was no longer statistically significant (Multivariable HR = 1.11; 95% CI 0.82-1.51). CONCLUSIONS: Micronutrient inadequacy in four or more micronutrients could exert a moderate role in the development of depression.
PURPOSE: The aim of the study was to prospectively assess the association between micronutrient intake adequacy and risk of depression. METHODS: This dynamic cohort study involves Spanish university graduates (SUN Project). Dietary intake was assessed at baseline and after 10 years of follow-up with a semi-quantitative food frequency questionnaire. Micronutrient intake adequacy for vitamins B1, B2, B3, B6, B12, C, A, D, E, folic acid, zinc, iodine, selenium, iron, calcium, potassium, phosphorus, magnesium and chrome was estimated. Inadequate intake for each nutrient was defined when the intake of the nutrient was below the estimated average requirements (EAR) if available or the adequate intake levels, if EARs were not available. We compared participants with inadequate intake for ≥4 nutrients vs. those with one nutrient. Participants were classified as having incident depression if they had no previous history of depression or antidepressants use at baseline, but they reported during follow-up a new clinical diagnosis of depression by a physician, use of antidepressant drugs, or both. Time-dependent multivariable Cox regression models were fitted. RESULTS: After a median follow-up of 8.5 years, 953 new cases of depression were observed among 13,983 participants. Participants with inadequate intake for ≥4 nutrients showed a significantly higher risk of depression [multivariable hazard ratio (HR) = 1.37; 95% confidence interval (CI) 1.01-1.85]. When the analyses were updated with repeated assessments of intakes, the association was attenuated and it was no longer statistically significant (Multivariable HR = 1.11; 95% CI 0.82-1.51). CONCLUSIONS: Micronutrient inadequacy in four or more micronutrients could exert a moderate role in the development of depression.
Authors: Marie-Laure Derom; Miguel A Martínez-González; Maria del Carmen Sayón-Orea; Maira Bes-Rastrollo; Juan J Beunza; Almudena Sánchez-Villegas Journal: J Nutr Date: 2012-04-18 Impact factor: 4.798
Authors: Ana Sánchez-Tainta; Itziar Zazpe; Maira Bes-Rastrollo; Jordi Salas-Salvadó; Mónica Bullo; José Vicente Sorlí; Dolores Corella; M Isabel Covas; Fernando Arós; Mario Gutierrez-Bedmar; Miquel Fiol; F García de la Corte; Lluis Serra-Majem; Xavier Pinto; Helmut Schröeder; Emilio Ros; M Carmen López-Sabater; Ramón Estruch; Miguel Angel Martínez-González Journal: Eur J Nutr Date: 2015-01-24 Impact factor: 5.614
Authors: Carmen de la Fuente-Arrillaga; Zenaida Vázquez Ruiz; Maira Bes-Rastrollo; Laura Sampson; Miguel Angel Martinez-González Journal: Public Health Nutr Date: 2010-01-28 Impact factor: 4.022
Authors: Arpita Das; Robert G Cumming; Vasi Naganathan; Rosilene V Ribeiro; David G Le Couteur; David J Handelsman; Louise M Waite; Vasant Hirani Journal: Eur J Nutr Date: 2020-05-08 Impact factor: 5.614
Authors: Cielo García-Montero; Miguel A Ortega; Miguel Angel Alvarez-Mon; Oscar Fraile-Martinez; Adoración Romero-Bazán; Guillermo Lahera; José Manuel Montes-Rodríguez; Rosa M Molina-Ruiz; Fernando Mora; Roberto Rodriguez-Jimenez; Javier Quintero; Melchor Álvarez-Mon Journal: Nutrients Date: 2022-03-06 Impact factor: 5.717