Aurora Perez-Cornago1, Patricia Lopez-Legarrea2, Rocio de la Iglesia3, Francisca Lahortiga4, J Alfredo Martinez5, M Angeles Zulet6. 1. Department of Nutrition, Food Science and Physiology, University of Navarra, C/Irunlarrea 1, 31008 Pamplona, Spain. Electronic address: apcornago@alumni.unav.es. 2. Department of Nutrition, Food Science and Physiology, University of Navarra, C/Irunlarrea 1, 31008 Pamplona, Spain. Electronic address: pllegarrea@alumni.unav.es. 3. Department of Nutrition, Food Science and Physiology, University of Navarra, C/Irunlarrea 1, 31008 Pamplona, Spain. Electronic address: rdelaiglesi@alumni.unav.es. 4. Department of Psychiatry and Medical Psychology, University Clinic of Navarra, Av/Pío XII 36, 31008 Pamplona, Spain. Electronic address: flahortiga@unav.es. 5. Department of Nutrition, Food Science and Physiology, University of Navarra, C/Irunlarrea 1, 31008 Pamplona, Spain; CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Spain. Electronic address: jalftmtz@unav.es. 6. Department of Nutrition, Food Science and Physiology, University of Navarra, C/Irunlarrea 1, 31008 Pamplona, Spain; CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Spain. Electronic address: mazulet@unav.es.
Abstract
BACKGROUND & AIM: Metabolic syndrome and depression seem to share some common underlying mechanisms, although less is known about the impact of metabolic syndrome dietary treatments on depression. This study examined the association between a hypocaloric treatment designed to reduce metabolic syndrome features in self-perceived depression and the potential involvement of dietary components and oxidative stress changes. METHODS: Analyses were based on volunteers (n = 55) with metabolic syndrome (age 50 ± 1 y.o.; 38M/17F), where depressive symptoms were assessed using the Beck Depression Inventory. Participants followed two hypocaloric diets (control diet and RESMENA diet) with the same energy restriction (-30% TCV) for six months. Depressive symptoms, dietary records, anthropometrical measurements, biochemical parameters and oxidative stress levels were analysed. RESULTS: Both diets improved self-perceived depression similarly (p = 0.528). Participants with lower depressive symptoms at baseline reported a significantly higher intake of omega-3 polyunsaturated fatty acids (p trend = 0.002). Interestingly, after adjusting for potential confounders, the increase in folate consumption (p = 0.011) and the decrease in plasma malondialdehyde levels (p = 0.012) throughout the intervention, were associated with the improvement in depressive symptoms. CONCLUSIONS: A higher intake of folate and a decline in malondialdehyde plasma levels during a weight loss intervention, were related to improvements in manifestations of depression (www.clinicaltrials.gov; NCT01087086).
RCT Entities:
BACKGROUND & AIM: Metabolic syndrome and depression seem to share some common underlying mechanisms, although less is known about the impact of metabolic syndrome dietary treatments on depression. This study examined the association between a hypocaloric treatment designed to reduce metabolic syndrome features in self-perceived depression and the potential involvement of dietary components and oxidative stress changes. METHODS: Analyses were based on volunteers (n = 55) with metabolic syndrome (age 50 ± 1 y.o.; 38M/17F), where depressive symptoms were assessed using the Beck Depression Inventory. Participants followed two hypocaloric diets (control diet and RESMENA diet) with the same energy restriction (-30% TCV) for six months. Depressive symptoms, dietary records, anthropometrical measurements, biochemical parameters and oxidative stress levels were analysed. RESULTS: Both diets improved self-perceived depression similarly (p = 0.528). Participants with lower depressive symptoms at baseline reported a significantly higher intake of omega-3 polyunsaturated fatty acids (p trend = 0.002). Interestingly, after adjusting for potential confounders, the increase in folate consumption (p = 0.011) and the decrease in plasma malondialdehyde levels (p = 0.012) throughout the intervention, were associated with the improvement in depressive symptoms. CONCLUSIONS: A higher intake of folate and a decline in malondialdehyde plasma levels during a weight loss intervention, were related to improvements in manifestations of depression (www.clinicaltrials.gov; NCT01087086).
Authors: Rodrigo B Mansur; Graccielle R Cunha; Elson Asevedo; André Zugman; Adiel C Rios; Giovanni A Salum; Pedro M Pan; Ary Gadelha; Mateus L Levandowski; Síntia I Belangero; Gisele G Manfro; Laura Stertz; Márcia Kauer-Sant'anna; Eurípedes C Miguel; Rodrigo A Bressan; Jair J Mari; Rodrigo Grassi-Oliveira; Elisa Brietzke Journal: Eur Child Adolesc Psychiatry Date: 2016-10-26 Impact factor: 4.785
Authors: Carolina Ferreira Nicoletti; Carla Barbosa Nonino; Bruno Affonso Parenti de Oliveira; Marcela Augusta de Souza Pinhel; Maria Luisa Mansego; Fermin Ignacio Milagro; Maria Angeles Zulet; José Alfredo Martinez Journal: Obes Surg Date: 2016-03 Impact factor: 4.129
Authors: M Angeles Zulet; Itziar Abete; Cristina Galarregui; Irene Cantero; Bertha Araceli Marin-Alejandre; J Ignacio Monreal; Mariana Elorz; Alberto Benito-Boillos; José Ignacio Herrero; Víctor de la O; Miguel Ruiz-Canela; Helen Hermana M Hermsdorff; Josefina Bressan; Josep A Tur; J Alfredo Martínez Journal: Eur J Nutr Date: 2020-08-28 Impact factor: 5.614
Authors: Aurora Perez-Cornago; Rocio de la Iglesia; Patricia Lopez-Legarrea; Itziar Abete; Santiago Navas-Carretero; Clara I Lacunza; Francisca Lahortiga; Miguel A Martinez-Gonzalez; J Alfredo Martinez; M Angeles Zulet Journal: Nutr J Date: 2014-04-24 Impact factor: 3.271
Authors: Rocio de la Iglesia; Maria L Mansego; Francisco J Sánchez-Muniz; M Angeles Zulet; J Alfredo Martinez Journal: EXCLI J Date: 2014-04-09 Impact factor: 4.068