Yueh-Hsiu Mathilda Chiu1, Birgit Claus Henn2, Hsiao-Hsien Leon Hsu3, Mathew P Pendo4, Brent A Coull5, Christine Austin3, Giuseppa Cagna6, Chiara Fedrighi6, Donatella Placidi6, Donald R Smith7, Robert O Wright8, Roberto G Lucchini9, Manish Arora3. 1. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: mathilda.chiu@mssm.edu. 2. Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA. 3. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 4. Center for Medicine, Health and Society, Vanderbilt University College of Arts and Science, Nashville, TN, USA. 5. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 6. Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Section of Occupational Medicine, University of Brescia, Brescia, Italy. 7. Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, USA. 8. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 9. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Section of Occupational Medicine, University of Brescia, Brescia, Italy.
Abstract
INTRODUCTION: While studies have suggested that exposure to manganese (Mn) may be associated with neurodevelopment in school-age children, there is limited information on prenatal and postnatal Mn exposures and tremor or motor function in children. METHODS: We measured Mn levels in dentine of shed teeth, representing prenatal, early postnatal, and cumulative childhood exposure windows, from 195 children (predominantly right-handed, 92%) in Italy. Pursuit Aiming, Luria Nebraska Motor Battery, as well as Tremor and Sway system from Computerized Adaptive Testing System (CATSYS) were administered at 11-14 years old. We examined the relationships of tooth Mn (ln-transformed) with motor function using multivariable linear regressions and generalized additive models, adjusting for age, sex, and socioeconomic status index. Effect modification by sex was also examined. RESULTS: We found that higher prenatal Mn was associated with better body stability in boys in a number of sway tests (including mean sway, transversal sway, sagittal sway, sway area, and sway intensity), while Mn was associated with poorer performance in girls on all of these metrics (all p for Mn × sex interaction < 0.05). Higher prenatal Mn was also modestly associated with better hand/finger and eye-hand coordination in boys compared to girls in sex-stratified analyses, although interaction models did not reach statistical significance. For tremor, on the other hand, higher early postnatal Mn was associated with increased right-hand center frequency in girls (p for interaction < 0.01), but increased Mn level at the later postnatal period was associated with increased center frequency in boys (p for interaction = 0.01). CONCLUSIONS: This study, which used a direct measure of prenatal and childhood Mn exposure, suggested sex-specific critical windows of early life Mn exposure in relation to neuromotor function in adolescents. The sex-specific associations might be strongest with measures of whole body stability, for which the critical exposure window was during the prenatal period.
INTRODUCTION: While studies have suggested that exposure to manganese (Mn) may be associated with neurodevelopment in school-age children, there is limited information on prenatal and postnatal Mn exposures and tremor or motor function in children. METHODS: We measured Mn levels in dentine of shed teeth, representing prenatal, early postnatal, and cumulative childhood exposure windows, from 195 children (predominantly right-handed, 92%) in Italy. Pursuit Aiming, Luria Nebraska Motor Battery, as well as Tremor and Sway system from Computerized Adaptive Testing System (CATSYS) were administered at 11-14 years old. We examined the relationships of tooth Mn (ln-transformed) with motor function using multivariable linear regressions and generalized additive models, adjusting for age, sex, and socioeconomic status index. Effect modification by sex was also examined. RESULTS: We found that higher prenatal Mn was associated with better body stability in boys in a number of sway tests (including mean sway, transversal sway, sagittal sway, sway area, and sway intensity), while Mn was associated with poorer performance in girls on all of these metrics (all p for Mn × sex interaction < 0.05). Higher prenatal Mn was also modestly associated with better hand/finger and eye-hand coordination in boys compared to girls in sex-stratified analyses, although interaction models did not reach statistical significance. For tremor, on the other hand, higher early postnatal Mn was associated with increased right-hand center frequency in girls (p for interaction < 0.01), but increased Mn level at the later postnatal period was associated with increased center frequency in boys (p for interaction = 0.01). CONCLUSIONS: This study, which used a direct measure of prenatal and childhood Mn exposure, suggested sex-specific critical windows of early life Mn exposure in relation to neuromotor function in adolescents. The sex-specific associations might be strongest with measures of whole body stability, for which the critical exposure window was during the prenatal period.
Authors: Michael Aschner; Keith M Erikson; Elena Herrero Hernández; Elena Herrero Hernández; Ronald Tjalkens Journal: Neuromolecular Med Date: 2009 Impact factor: 3.843
Authors: Miyoung Yoon; Jeffry D Schroeter; Andy Nong; Michael D Taylor; David C Dorman; Melvin E Andersen; Harvey J Clewell Journal: Toxicol Sci Date: 2011-05-27 Impact factor: 4.849
Authors: Samrat Yeramaneni; Kim N Dietrich; Kimberly Yolton; Patrick J Parsons; Kenneth M Aldous; Erin N Haynes Journal: J Pediatr Date: 2015-04-14 Impact factor: 4.406
Authors: A T Yamagata; N C Guimarães; D F Santana; M R Gonçalves; V C O Souza; F Barbosa Júnior; J E Pandossio; V S Santos Journal: Toxicology Date: 2016-05-12 Impact factor: 4.221
Authors: David C Dorman; Brian E McManus; Marianne W Marshall; R Arden James; Melanie F Struve Journal: Toxicol Appl Pharmacol Date: 2004-06-01 Impact factor: 4.219
Authors: Karin Broberg; Tahir Taj; Stefano Guazzetti; Marco Peli; Giuseppa Cagna; Daniela Pineda; Donatella Placidi; Robert O Wright; Donald R Smith; Roberto G Lucchini; Karin Wahlberg Journal: Environ Int Date: 2019-06-22 Impact factor: 9.621
Authors: Kerem C Gurol; Michael Aschner; Donald R Smith; Somshuvra Mukhopadhyay Journal: Am J Physiol Gastrointest Liver Physiol Date: 2021-11-17 Impact factor: 4.052
Authors: Erik de Water; Paul Curtin; Chris Gennings; John J Chelonis; Merle Paule; Moira Bixby; Nia McRae; Katherine Svensson; Lourdes Schnaas; Ivan Pantic; Martha M Téllez-Rojo; Robert O Wright; Megan K Horton Journal: Neurotoxicology Date: 2021-11-15 Impact factor: 4.398
Authors: Max T Aung; John D Meeker; Jonathan Boss; Kelly M Bakulski; Bhramar Mukherjee; David E Cantonwine; Thomas F McElrath; Kelly K Ferguson Journal: Reprod Toxicol Date: 2019-12-24 Impact factor: 3.143
Authors: Julia Anglen Bauer; Roberta F White; Brent A Coull; Christine Austin; Manuela Oppini; Silvia Zoni; Chiara Fedrighi; Giuseppa Cagna; Donatella Placidi; Stefano Guazzetti; Qiong Yang; David C Bellinger; Thomas F Webster; Robert O Wright; Donald Smith; Megan Horton; Roberto G Lucchini; Manish Arora; Birgit Claus Henn Journal: Neurotoxicology Date: 2021-08-31 Impact factor: 4.294
Authors: Megan K Horton; Leon Hsu; Birgit Claus Henn; Amy Margolis; Christine Austin; Katherine Svensson; Lourdes Schnaas; Chris Gennings; Howard Hu; Robert Wright; Martha María Téllez Rojo; Manish Arora Journal: Environ Int Date: 2018-09-08 Impact factor: 13.352
Authors: Birgit Claus Henn; Christine Austin; Brent A Coull; Lourdes Schnaas; Chris Gennings; Megan K Horton; Mauricio Hernández-Ávila; Howard Hu; Martha Maria Téllez-Rojo; Robert O Wright; Manish Arora Journal: Environ Res Date: 2018-02 Impact factor: 8.431