| Literature DB >> 32892263 |
Mohammad H Rahbar1,2,3, Maureen Samms-Vaughan4, Sepideh Saroukhani5,6, MinJae Lee7,8, Jing Zhang6,9, Jan Bressler5,10, Manouchehr Hessabi6, Sydonnie Shakespeare-Pellington4, Megan L Grove5,10, Katherine A Loveland11.
Abstract
Using data from 266 age- and sex-matched pairs of Jamaican children with autism spectrum disorder (ASD) and typically developing (TD) controls (2-8 years), we investigated whether glutathione S-transferase theta 1 (GSTT1) modifies the association between blood manganese concentrations (BMC) and ASD. After adjusting conditional logistic regression models for socioeconomic status and the interaction between GSTT1 and GSTP1 (glutathione S-transferase pi 1), using a recessive genetic model for GSTT1 and either a co-dominant or dominant model for GSTP1, the interaction between GSTT1 and BMC was significant (P = 0.02, P = 0.01, respectively). Compared to controls, ASD cases with GSTT1-DD genotype had 4.33 and 4.34 times higher odds of BMC > 12 vs. ≤ 8.3 μg/L, respectively. Replication in other populations is warranted.Entities:
Keywords: Autism spectrum disorder (ASD); Blood manganese concentrations (BMC); Conditional logistic regression (CLR); Glutathione S-transferase (GST) genes; Interaction; Jamaica
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Year: 2021 PMID： 32892263 PMCID： PMC7936003 DOI： 10.1007/s10803-020-04677-z
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257