Literature DB >> 28839830

Do critically ill liver patients experience negative bias? A web-based survey examining doctors opinions to critical care escalation.

Philip A Berry1, Marcus Peck2, Tom Standley3, Sam J Thomson4.   

Abstract

OBJECTIVE: To test the hypothesis that there is negative bias towards escalating levels of care in decompensated cirrhosis, compared with other patient groups.
DESIGN: An electronic survey containing eight acute clinical scenarios with equivalent physiological derangement, in which respondents were asked to score the degree to which they would advocate for intensive care unit admission on a scale of 1-10. Scenarios included respiratory, haematology, vascular, renal, gastrointestinal, postoperative and hepatological conditions. Follow-up questions examined the reasons why the patient should or should not be transferred, and enquired about ceilings of care, end-of-life decisions, degree of organ support and healthcare financial rationing. 273 doctors responded.
SETTING: Secondary care hospitals in south of England. PATIENTS: None involved.
INTERVENTIONS: None. MAIN OUTCOME MEASURES: Advocacy score (1-10) and subsidiary responses.
RESULTS: The hepatology patient ranked 4th of 8 with a mean advocacy score of 7.2. There were no significant differences between intensivists and physicians or between grades of seniority. Of those less likely to escalate (score 1-5, n=42), the reasons given were based on unsurvivability or excessive burden of treatment rather than aetiology. One-fifth cited 'lifestyle decision'. 25 (62.5%) respondents not favouring escalation would make the patient DNACPR, 17 (42.5%) would stipulate ward-based care only and a small minority would instigate active palliation. Of those favouring escalation (advocacy score 6-10), 70% (n=122) would consider unlimited organ support. Fifty-four (29.5% of those who answered) said they 'sometimes' or 'frequently' consider resource allocation when making decisions about escalation of care.
CONCLUSIONS: When compared with a variety of acute medical scenarios, doctors did not overly appear to exhibit therapeutic nihilism for patients with decompensated liver disease; however, significant variation in interpretation of the data and management approaches was identified.

Entities:  

Keywords:  ALCOHOLIC LIVER DISEASE; CIRRHOSIS; LIVER FAILURE; MEDICAL DECISION ANALYSIS

Year:  2015        PMID: 28839830      PMCID: PMC5369518          DOI: 10.1136/flgastro-2015-100608

Source DB:  PubMed          Journal:  Frontline Gastroenterol        ISSN: 2041-4137


  10 in total

1.  Outcomes of critically ill patients with cirrhosis admitted to intensive care: an important perspective from the non-transplant setting.

Authors:  S J Thomson; C Moran; M L Cowan; S Musa; R Beale; D Treacher; M Hamilton; R M Grounds; T M Rahman
Journal:  Aliment Pharmacol Ther       Date:  2010-04-29       Impact factor: 8.171

2.  Predictions and outcomes for the critically ill patient with cirrhosis: is it time to settle on the SOFA and let jaundiced views on outcome MELD away?

Authors:  Stephen J Warrillow
Journal:  Crit Care Med       Date:  2010-11       Impact factor: 7.598

3.  Prognostic models in cirrhotics admitted to intensive care units better predict outcome when assessed at 48 h after admission.

Authors:  Evangelos Cholongitas; Alex Betrosian; Marco Senzolo; Steve Shaw; David Patch; Pinelopi Manousou; James O'Beirne; Andrew K Burroughs
Journal:  J Gastroenterol Hepatol       Date:  2007-12-13       Impact factor: 4.029

4.  The increasing burden of alcoholic liver disease on United Kingdom critical care units: secondary analysis of a high quality clinical database.

Authors:  Catherine Welch; David Harrison; Alasdair Short; Kathryn Rowan
Journal:  J Health Serv Res Policy       Date:  2008-04

5.  Risk factors, sequential organ failure assessment and model for end-stage liver disease scores for predicting short term mortality in cirrhotic patients admitted to intensive care unit.

Authors:  E Cholongitas; M Senzolo; D Patch; K Kwong; V Nikolopoulou; G Leandro; S Shaw; A K Burroughs
Journal:  Aliment Pharmacol Ther       Date:  2006-04-01       Impact factor: 8.171

6.  Prognosis of patients with cirrhosis and chronic liver disease admitted to the medical intensive care unit.

Authors:  R G Shellman; W J Fulkerson; E DeLong; C A Piantadosi
Journal:  Crit Care Med       Date:  1988-07       Impact factor: 7.598

Review 7.  Review article: towards a considered and ethical approach to organ support in critically-ill patients with cirrhosis.

Authors:  P A Berry; S J Thomson; T M Rahman; A Ala
Journal:  Aliment Pharmacol Ther       Date:  2012-11-16       Impact factor: 8.171

8.  Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis.

Authors:  Richard Moreau; Rajiv Jalan; Pere Gines; Marco Pavesi; Paolo Angeli; Juan Cordoba; Francois Durand; Thierry Gustot; Faouzi Saliba; Marco Domenicali; Alexander Gerbes; Julia Wendon; Carlo Alessandria; Wim Laleman; Stefan Zeuzem; Jonel Trebicka; Mauro Bernardi; Vicente Arroyo
Journal:  Gastroenterology       Date:  2013-03-06       Impact factor: 22.682

9.  Should alcoholics compete equally for liver transplantation?

Authors:  A H Moss; M Siegler
Journal:  JAMA       Date:  1991-03-13       Impact factor: 56.272

10.  The impact of organ dysfunction in cirrhosis: survival at a cost?

Authors:  Debbie L Shawcross; Mark J Austin; Robin Daniel Abeles; Mark J W McPhail; Andrew D Yeoman; Nicholas J Taylor; Andrew J Portal; Khaleel Jamil; Georg Auzinger; Elizabeth Sizer; William Bernal; Julia A Wendon
Journal:  J Hepatol       Date:  2012-01-13       Impact factor: 25.083

  10 in total

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