Literature DB >> 18416928

The increasing burden of alcoholic liver disease on United Kingdom critical care units: secondary analysis of a high quality clinical database.

Catherine Welch1, David Harrison, Alasdair Short, Kathryn Rowan.   

Abstract

OBJECTIVES: To investigate the effect of increasing alcohol consumption on the number of admissions to adult, general critical/intensive care units (ICUs) in England and Wales with alcoholic liver disease, their case mix, mortality, and impact on critical care and hospital activity by extrapolating from admissions to ICUs over the last 10 years.
METHODS: Secondary analysis of a high quality clinical database from a national clinical audit using data from 385,429 admissions to174 ICUs in England and Wales between December 1995 and July 2005, of which 4219 (1.1%) had alcoholic liver disease. The extrapolated total number of admissions with alcoholic liver disease and total number of ICU bed-days occupied were calculated. Changes over time in the case mix (age, sex and APACHE II and ICNARC risk prediction models), mortality at ultimate discharge from acute hospital, and length of stay in ICU and in hospital were explored.
RESULTS: The percentage of ICU admissions with alcoholic liver disease increased from 0.65% in 1996 to 1.35% in 2005, but the case mix remained similar. Mortality decreased and length of stay increased over this period. The extrapolated total number of admissions to all 229 adult, general critical care units in England and Wales increased from 550 in 1996 to 1513 in 2005, and the extrapolated total number of bed-days occupied by these admissions increased from around 3100 to over 10,000.
CONCLUSIONS: Admissions to ICUs in England and Wales with alcoholic liver disease tripled over the 10-year period from 1996 to 2005. The continuing increase in alcohol consumption means that this trend is likely to continue.

Entities:  

Mesh:

Year:  2008        PMID: 18416928     DOI: 10.1258/jhsrp.2007.007101

Source DB:  PubMed          Journal:  J Health Serv Res Policy        ISSN: 1355-8196


  10 in total

1.  Respiratory responses of Gillichthys mirabilis to changes in temperature, dissolved oxygen and salinity.

Authors:  L A Courtois
Journal:  Comp Biochem Physiol A Comp Physiol       Date:  1976-01

Review 2.  Hepatosplanchnic circulation in cirrhosis and sepsis.

Authors:  Meghan Prin; Jan Bakker; Gebhard Wagener
Journal:  World J Gastroenterol       Date:  2015-03-07       Impact factor: 5.742

3.  Do critically ill liver patients experience negative bias? A web-based survey examining doctors opinions to critical care escalation.

Authors:  Philip A Berry; Marcus Peck; Tom Standley; Sam J Thomson
Journal:  Frontline Gastroenterol       Date:  2015-08-11

4.  Alcoholic liver disease on the intensive care unit - Outcomes and prognostication.

Authors:  James I Beck; Anca Staicu; Simon M Everett; Phil Jackson
Journal:  J Intensive Care Soc       Date:  2016-08-03

5.  Long-Term Mortality and Hospital Resource Use in ICU Patients With Alcohol-Related Liver Disease.

Authors:  Nazir I Lone; Robert Lee; Timothy S Walsh
Journal:  Crit Care Med       Date:  2019-01       Impact factor: 7.598

6.  Predicting outcome in liver patients admitted to intensive care: A dual-centre non-specialist hospital external validation of the Liver injury and Failure evaluation score.

Authors:  Eleanor de Sausmarez; Paul Crowest; Steve Fry; Luke Hodgson
Journal:  J Intensive Care Soc       Date:  2020-05-08

7.  Comorbidity and survival after admission to the intensive care unit: A population-based study of 41,230 patients.

Authors:  Alasdair Simpson; Kathryn Puxty; Philip McLoone; Tara Quasim; Billy Sloan; David S Morrison
Journal:  J Intensive Care Soc       Date:  2020-04-15

8.  Trends in the epidemiological aspects and mortality of alcoholic liver disease in Korea in the decade between 2000 and 2009.

Authors:  Hyung-Ae Bang; Young-Hwan Kwon; Myeong-Jin Lee; Won-Chang Lee
Journal:  J Clin Med Res       Date:  2014-11-19

9.  Trends in alcohol-related admissions to hospital by age, sex and socioeconomic deprivation in England, 2002/03 to 2013/14.

Authors:  Mark A Green; Mark Strong; Lucy Conway; Ravi Maheswaran
Journal:  BMC Public Health       Date:  2017-05-08       Impact factor: 3.295

10.  A multicentre prospective evaluation of alcohol-related admissions to intensive care units in Wales.

Authors:  Ceri Lynch; Richard Pugh; Ceri Battle
Journal:  J Intensive Care Soc       Date:  2017-03-21
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.