Literature DB >> 28818634

Mining Naïve Rabbit Antibody Repertoires by Phage Display for Monoclonal Antibodies of Therapeutic Utility.

Haiyong Peng1, Thomas Nerreter2, Jing Chang1, Junpeng Qi1, Xiuling Li1, Pabalu Karunadharma3, Gustavo J Martinez3, Mohammad Fallahi4, Jo Soden5, Jim Freeth5, Roger R Beerli6, Ulf Grawunder6, Michael Hudecek2, Christoph Rader7.   

Abstract

Owing to their high affinities and specificities, rabbit monoclonal antibodies (mAbs) have demonstrated value and potential primarily as basic research and diagnostic reagents, but, in some cases, also as therapeutics. To accelerate access to rabbit mAbs bypassing immunization, we generated a large naïve rabbit antibody repertoire represented by a phage display library encompassing >10 billion independent antibodies in chimeric rabbit/human Fab format and validated it by next-generation sequencing. Panels of rabbit mAbs selected from this library against two emerging cancer targets, ROR1 and ROR2, revealed high diversity, affinity, and specificity. Moreover, ROR1- and ROR2-targeting rabbit mAbs demonstrated therapeutic utility as components of chimeric antigen receptor-engineered T cells, further corroborating the value of the naïve rabbit antibody library as a rich and virtually unlimited source of rabbit mAbs.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  ROR1; ROR2; antibody engineering; cancer therapy; chimeric antigen receptors

Mesh：

Substances：

Year:  2017        PMID： 28818634      PMCID： PMC5610937          DOI： 10.1016/j.jmb.2017.08.003

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  58 in total

1.  E. coli expression and purification of Fab antibody fragments.

Authors:  Ka Yin Kwong; Christoph Rader
Journal:  Curr Protoc Protein Sci       Date:  2009-02

2.  An efficient route to human bispecific IgG.

Authors:  A M Merchant; Z Zhu; J Q Yuan; A Goddard; C W Adams; L G Presta; P Carter
Journal:  Nat Biotechnol       Date:  1998-07       Impact factor: 54.908

3.  NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.

Authors:  Tomoya Yamaguchi; Kiyoshi Yanagisawa; Ryoji Sugiyama; Yasuyuki Hosono; Yukako Shimada; Chinatsu Arima; Seiichi Kato; Shuta Tomida; Motoshi Suzuki; Hirotaka Osada; Takashi Takahashi
Journal:  Cancer Cell       Date:  2012-03-20       Impact factor: 31.743

4.  Transpo-mAb display: Transposition-mediated B cell display and functional screening of full-length IgG antibody libraries.

Authors:  Lorenz Waldmeier; Ina Hellmann; Chantal K Gutknecht; Fabian I Wolter; Skylar C Cook; Sai T Reddy; Ulf Grawunder; Roger R Beerli
Journal:  MAbs       Date:  2016-03-17       Impact factor: 5.857

5.  Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev.

Authors:  Stephen J Stahl; Norman R Watts; Christoph Rader; Michael A DiMattia; Rose G Mage; Ira Palmer; Joshua D Kaufman; Jonathan M Grimes; David I Stuart; Alasdair C Steven; Paul T Wingfield
Journal:  J Mol Biol       Date:  2010-02-04       Impact factor: 5.469

6.  Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis.

Authors:  Bing Cui; Suping Zhang; Liguang Chen; Jianqiang Yu; George F Widhopf; Jessie-F Fecteau; Laura Z Rassenti; Thomas J Kipps
Journal:  Cancer Res       Date:  2013-06-15       Impact factor: 12.701

7.  Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication.

Authors:  Miguel Carneiro; Carl-Johan Rubin; Federica Di Palma; Nuno Ferrand; Kerstin Lindblad-Toh; Leif Andersson; Frank W Albert; Jessica Alföldi; Alvaro Martinez Barrio; Gerli Pielberg; Nima Rafati; Shumaila Sayyab; Jason Turner-Maier; Shady Younis; Sandra Afonso; Bronwen Aken; Joel M Alves; Daniel Barrell; Gerard Bolet; Samuel Boucher; Hernán A Burbano; Rita Campos; Jean L Chang; Veronique Duranthon; Luca Fontanesi; Hervé Garreau; David Heiman; Jeremy Johnson; Rose G Mage; Ze Peng; Guillaume Queney; Claire Rogel-Gaillard; Magali Ruffier; Steve Searle; Rafael Villafuerte; Anqi Xiong; Sarah Young; Karin Forsberg-Nilsson; Jeffrey M Good; Eric S Lander
Journal:  Science       Date:  2014-08-29       Impact factor: 47.728

Review 8.  Ror2 as a therapeutic target in cancer.

Authors:  Zufan Debebe; W Kimryn Rathmell
Journal:  Pharmacol Ther       Date:  2015-01-19       Impact factor: 13.400

Review 9.  From rabbit antibody repertoires to rabbit monoclonal antibodies.

Authors:  Justus Weber; Haiyong Peng; Christoph Rader
Journal:  Exp Mol Med       Date:  2017-03-24       Impact factor: 8.718

10.  Systematic characterization and comparative analysis of the rabbit immunoglobulin repertoire.

Authors:  Jason J Lavinder; Kam Hon Hoi; Sai T Reddy; Yariv Wine; George Georgiou
Journal:  PLoS One       Date:  2014-06-30       Impact factor: 3.240
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  17 in total

1.  Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues.

Authors:  Dobeen Hwang; Napon Nilchan; Alex R Nanna; Xiaohai Li; Michael D Cameron; William R Roush; HaJeung Park; Christoph Rader
Journal:  Cell Chem Biol       Date:  2019-06-20       Impact factor: 8.116

2.  A Sortase A Programmable Phage Display Format for Improved Panning of Fab Antibody Libraries.

Authors:  Henry D Wilson; Xiuling Li; Haiyong Peng; Christoph Rader
Journal:  J Mol Biol       Date:  2018-09-11       Impact factor: 5.469

3.  Isolation of rabbit single domain antibodies to B7-H3 via protein immunization and phage display.

Authors:  Ruonan Feng; Ruixue Wang; Jessica Hong; Christopher M Dower; Brad St Croix; Mitchell Ho
Journal:  Antib Ther       Date:  2020-02-17

4.  Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.

Authors:  Junpeng Qi; Xiuling Li; Haiyong Peng; Erika M Cook; Eman L Dadashian; Adrian Wiestner; HaJeung Park; Christoph Rader
Journal:  Proc Natl Acad Sci U S A       Date:  2018-05-29       Impact factor: 11.205

5.  Siglec-6 on Chronic Lymphocytic Leukemia Cells Is a Target for Post-Allogeneic Hematopoietic Stem Cell Transplantation Antibodies.

Authors:  Jing Chang; Haiyong Peng; Brian C Shaffer; Sivasubramanian Baskar; Ina C Wecken; Matthew G Cyr; Gustavo J Martinez; Jo Soden; Jim Freeth; Adrian Wiestner; Christoph Rader
Journal:  Cancer Immunol Res       Date:  2018-07-06       Impact factor: 11.151

6.  ROR1-targeting switchable CAR-T cells for cancer therapy.

Authors:  Haiyong Peng; Thomas Nerreter; Katrin Mestermann; Jakob Wachter; Jing Chang; Michael Hudecek; Christoph Rader
Journal:  Oncogene       Date:  2022-07-20       Impact factor: 8.756

7.  Identification of New Antibodies Targeting Malignant Plasma Cells for Immunotherapy by Next-Generation Sequencing-Assisted Phage Display.

Authors:  Steffen Krohn; Ammelie Svea Boje; Carina Lynn Gehlert; Sebastian Lutz; Nikos Darzentas; Henrik Knecht; Dietrich Herrmann; Monika Brüggemann; Axel J Scheidig; Katja Weisel; Martin Gramatzki; Matthias Peipp; Katja Klausz
Journal:  Front Immunol       Date:  2022-06-17       Impact factor: 8.786

8.  Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.

Authors:  Rebecca S Goydel; Justus Weber; Haiyong Peng; Junpeng Qi; Jo Soden; Jim Freeth; HaJeung Park; Christoph Rader
Journal:  J Biol Chem       Date:  2020-03-19       Impact factor: 5.157

9.  Phage display peptide libraries: deviations from randomness and correctives.

Authors:  Arie Ryvkin; Haim Ashkenazy; Yael Weiss-Ottolenghi; Chen Piller; Tal Pupko; Jonathan M Gershoni
Journal:  Nucleic Acids Res       Date:  2018-05-18       Impact factor: 16.971

Review 10.  Next-Generation Sequencing of Antibody Display Repertoires.

Authors:  Romain Rouet; Katherine J L Jackson; David B Langley; Daniel Christ
Journal:  Front Immunol       Date:  2018-02-02       Impact factor: 7.561
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